Noninvasive electromyometrial imaging of human uterine maturation during term labor

Hui Wang, Zichao Wen, Wenjie Wu, Zhexian Sun, Zulfia Kisrieva-Ware, Yiqi Lin, Sicheng Wang, Hansong Gao, Haonan Xu, Peinan Zhao, Qing Wang, George A. Macones, Alan L. Schwartz, Phillip Cuculich, Alison G. Cahill and Yong Wang ()
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Hui Wang: Washington University
Zichao Wen: Washington University School of Medicine
Wenjie Wu: Washington University School of Medicine
Zhexian Sun: Washington University School of Medicine
Zulfia Kisrieva-Ware: Washington University School of Medicine
Yiqi Lin: Washington University School of Medicine
Sicheng Wang: Washington University School of Medicine
Hansong Gao: Washington University School of Medicine
Haonan Xu: Washington University School of Medicine
Peinan Zhao: Washington University School of Medicine
Qing Wang: Washington University School of Medicine
George A. Macones: The University of Texas at Austin
Alan L. Schwartz: Washington University School of Medicine
Phillip Cuculich: Washington University School of Medicine
Alison G. Cahill: The University of Texas at Austin
Yong Wang: Washington University School of Medicine

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Electromyometrial imaging (EMMI) was recently developed to image the three-dimensional (3D) uterine electrical activation during contractions noninvasively and accurately in sheep. Herein we describe the development and application of a human EMMI system to image and evaluate 3D uterine electrical activation patterns at high spatial and temporal resolution during human term labor. We demonstrate the successful integration of the human EMMI system during subjects’ clinical visits to generate noninvasively the uterine surface electrical potential maps, electrograms, and activation sequence through an inverse solution using up to 192 electrodes distributed around the abdomen surface. Quantitative indices, including the uterine activation curve, are developed and defined to characterize uterine surface contraction patterns. We thus show that the human EMMI system can provide detailed 3D images and quantification of uterine contractions as well as novel insights into the role of human uterine maturation during labor progression.

Date: 2023
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DOI: 10.1038/s41467-023-36440-0

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