Impact of diet and host genetics on the murine intestinal mycobiome

Yask Gupta, Anna Lara Ernst, Artem Vorobyev, Foteini Beltsiou, Detlef Zillikens, Katja Bieber, Simone Sanna-Cherchi, Angela M. Christiano, Christian D. Sadik, Ralf J. Ludwig () and Tanya Sezin ()
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Yask Gupta: University of Lübeck
Anna Lara Ernst: University of Lübeck
Artem Vorobyev: University of Lübeck
Foteini Beltsiou: University of Lübeck
Detlef Zillikens: University of Lübeck
Katja Bieber: University of Lübeck
Simone Sanna-Cherchi: Columbia University Irving Medical Center
Angela M. Christiano: Columbia University Irving Medical Center
Christian D. Sadik: University of Lübeck
Ralf J. Ludwig: University of Lübeck
Tanya Sezin: University of Lübeck

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract The mammalian gut is home to a diverse microbial ecosystem, whose composition affects various physiological traits of the host. Next-generation sequencing-based metagenomic approaches demonstrated how the interplay of host genetics, bacteria, and environmental factors shape complex traits and clinical outcomes. However, the role of fungi in these complex interactions remains understudied. Here, using 228 males and 363 females from an advanced-intercross mouse line, we provide evidence that fungi are regulated by host genetics. In addition, we map quantitative trait loci associated with various fungal species to single genes in mice using whole genome sequencing and genotyping. Moreover, we show that diet and its’ interaction with host genetics alter the composition of fungi in outbred mice, and identify fungal indicator species associated with different dietary regimes. Collectively, in this work, we uncover an association of the intestinal fungal community with host genetics and a regulatory role of diet in this ecological niche.

Date: 2023
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DOI: 10.1038/s41467-023-36479-z

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