Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England

Vahé Nafilyan (), Charlotte R. Bermingham (), Isobel L. Ward, Jasper Morgan, Francesco Zaccardi, Kamlesh Khunti, Julie Stanborough, Amitava Banerjee and James C. Doidge
Additional contact information
Vahé Nafilyan: Office for National Statistics
Charlotte R. Bermingham: Office for National Statistics
Isobel L. Ward: Office for National Statistics
Jasper Morgan: Office for National Statistics
Francesco Zaccardi: University of Leicester
Kamlesh Khunti: University of Leicester
Julie Stanborough: Office for National Statistics
Amitava Banerjee: University College London
James C. Doidge: London School of Hygiene and Tropical Medicine

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Several studies have reported associations between COVID-19 vaccination and risk of cardiac diseases, especially in young people; the impact on mortality, however, remains unclear. We use national, linked electronic health data in England to assess the impact of COVID-19 vaccination and positive SARS-CoV-2 tests on the risk of cardiac and all-cause mortality in young people (12 to 29 years) using a self-controlled case series design. Here, we show there is no significant increase in cardiac or all-cause mortality in the 12 weeks following COVID-19 vaccination compared to more than 12 weeks after any dose. However, we find an increase in cardiac death in women after a first dose of non mRNA vaccines. A positive SARS-CoV-2 test is associated with increased cardiac and all-cause mortality among people vaccinated or unvaccinated at time of testing.

Date: 2023
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DOI: 10.1038/s41467-023-36494-0

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