Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis

Wen-Lan Yang, Weinan Qiu, Ting Zhang, Kai Xu, Zi-Juan Gu, Yu Zhou, Heng-Ji Xu, Zhong-Zhou Yang, Bin Shen, Yong-Liang Zhao, Qi Zhou, Ying Yang (), Wei Li (), Peng-Yuan Yang () and Yun-Gui Yang ()
Additional contact information
Wen-Lan Yang: Chinese Academy of Sciences and China National Center for Bioinformation
Weinan Qiu: Chinese Academy of Sciences and China National Center for Bioinformation
Ting Zhang: Chinese Academy of Sciences and China National Center for Bioinformation
Kai Xu: Chinese Academy of Sciences
Zi-Juan Gu: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Yu Zhou: Nanjing Medical University
Heng-Ji Xu: Chinese Academy of Sciences and China National Center for Bioinformation
Zhong-Zhou Yang: Nanjing University Medical School
Bin Shen: Nanjing Medical University
Yong-Liang Zhao: Chinese Academy of Sciences and China National Center for Bioinformation
Qi Zhou: Chinese Academy of Sciences
Ying Yang: Chinese Academy of Sciences and China National Center for Bioinformation
Wei Li: Chinese Academy of Sciences
Peng-Yuan Yang: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Yun-Gui Yang: Chinese Academy of Sciences and China National Center for Bioinformation

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract T helper 17 (Th17) cells are a subset of CD4+ T helper cells involved in the inflammatory response in autoimmunity. Th17 cells secrete Th17 specific cytokines, such as IL-17A and IL17-F, which are governed by the master transcription factor RoRγt. However, the epigenetic mechanism regulating Th17 cell function is still not fully understood. Here, we reveal that deletion of RNA 5-methylcytosine (m5C) methyltransferase Nsun2 in mouse CD4+ T cells specifically inhibits Th17 cell differentiation and alleviates Th17 cell-induced colitis pathogenesis. Mechanistically, RoRγt can recruit Nsun2 to chromatin regions of their targets, including Il17a and Il17f, leading to the transcription-coupled m5C formation and consequently enhanced mRNA stability. Our study demonstrates a m5C mediated cell intrinsic function in Th17 cells and suggests Nsun2 as a potential therapeutic target for autoimmune disease.

Date: 2023
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DOI: 10.1038/s41467-023-36595-w

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