Malaria-driven adaptation of MHC class I in wild bonobo populations

Emily E. Wroblewski (), Lisbeth A. Guethlein, Aaron G. Anderson, Weimin Liu, Yingying Li, Sara E. Heisel, Andrew Jesse Connell, Jean-Bosco N. Ndjango, Paco Bertolani, John A. Hart, Terese B. Hart, Crickette M. Sanz, David B. Morgan, Martine Peeters, Paul M. Sharp, Beatrice H. Hahn and Peter Parham
Additional contact information
Emily E. Wroblewski: Washington University in St. Louis
Lisbeth A. Guethlein: Stanford University School of Medicine
Aaron G. Anderson: Washington University in St. Louis
Weimin Liu: University of Pennsylvania
Yingying Li: University of Pennsylvania
Sara E. Heisel: Washington University in St. Louis
Andrew Jesse Connell: University of Pennsylvania
Jean-Bosco N. Ndjango: University of Kisangani
Paco Bertolani: University of Oxford
John A. Hart: Frankfurt Zoological Society, Lomami National Park Project
Terese B. Hart: Frankfurt Zoological Society, Lomami National Park Project
Crickette M. Sanz: Washington University in St. Louis
David B. Morgan: Lester E. Fisher Center for the Study and Conservation of Apes, Lincoln Park Zoo
Martine Peeters: University of Montpellier, INSERM
Paul M. Sharp: University of Edinburgh
Beatrice H. Hahn: University of Pennsylvania
Peter Parham: Stanford University School of Medicine

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract The malaria parasite Plasmodium falciparum causes substantial human mortality, primarily in equatorial Africa. Enriched in affected African populations, the B*53 variant of HLA-B, a cell surface protein that presents peptide antigens to cytotoxic lymphocytes, confers protection against severe malaria. Gorilla, chimpanzee, and bonobo are humans’ closest living relatives. These African apes have HLA-B orthologs and are infected by parasites in the same subgenus (Laverania) as P. falciparum, but the consequences of these infections are unclear. Laverania parasites infect bonobos (Pan paniscus) at only one (TL2) of many sites sampled across their range. TL2 spans the Lomami River and has genetically divergent subpopulations of bonobos on each side. Papa-B, the bonobo ortholog of HLA-B, includes variants having a B*53-like (B07) peptide-binding supertype profile. Here we show that B07 Papa-B occur at high frequency in TL2 bonobos and that malaria appears to have independently selected for different B07 alleles in the two subpopulations.

Date: 2023
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DOI: 10.1038/s41467-023-36623-9

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