Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice

Sen Qiao, Samer Alasmi, Amanda Wyatt, Philipp Wartenberg, Hongmei Wang, Michael Candlish, Debajyoti Das, Mari Aoki, Ramona Grünewald, Ziyue Zhou, Qinghai Tian, Qiang Yu, Viktoria Götz, Anouar Belkacemi, Ahsan Raza, Fabien Ectors, Kathrin Kattler, Gilles Gasparoni, Jörn Walter, Peter Lipp, Patrice Mollard, Daniel J. Bernard, Ersin Karatayli, Senem Ceren Karatayli, Frank Lammert and Ulrich Boehm ()
Additional contact information
Sen Qiao: Saarland University School of Medicine
Samer Alasmi: Saarland University School of Medicine
Amanda Wyatt: Saarland University School of Medicine
Philipp Wartenberg: Saarland University School of Medicine
Hongmei Wang: Saarland University School of Medicine
Michael Candlish: Saarland University School of Medicine
Debajyoti Das: Saarland University School of Medicine
Mari Aoki: Saarland University School of Medicine
Ramona Grünewald: Saarland University School of Medicine
Ziyue Zhou: McGill University
Qinghai Tian: Saarland University School of Medicine
Qiang Yu: Saarland University School of Medicine
Viktoria Götz: Saarland University School of Medicine
Anouar Belkacemi: Saarland University School of Medicine
Ahsan Raza: Saarland University School of Medicine
Fabien Ectors: Liège University
Kathrin Kattler: Saarland University
Gilles Gasparoni: Saarland University
Jörn Walter: Saarland University
Peter Lipp: Saarland University School of Medicine
Patrice Mollard: IGF, University of Montpellier, CNRS, INSERM
Daniel J. Bernard: McGill University
Ersin Karatayli: Saarland University Medical Center, Saarland University
Senem Ceren Karatayli: Saarland University Medical Center, Saarland University
Frank Lammert: Saarland University Medical Center, Saarland University
Ulrich Boehm: Saarland University School of Medicine

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Inter-organ communication is a major hallmark of health and is often orchestrated by hormones released by the anterior pituitary gland. Pituitary gonadotropes secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to regulate gonadal function and control fertility. Whether FSH and LH also act on organs other than the gonads is debated. Here, we find that gonadotrope depletion in adult female mice triggers profound hypogonadism, obesity, glucose intolerance, fatty liver, and bone loss. The absence of sex steroids precipitates these phenotypes, with the notable exception of fatty liver, which results from ovary-independent actions of FSH. We uncover paracrine FSH action on pituitary corticotropes as a mechanism to restrain the production of corticosterone and prevent hepatic steatosis. Our data demonstrate that functional communication of two distinct hormone-secreting cell populations in the pituitary regulates hepatic lipid metabolism.

Date: 2023
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DOI: 10.1038/s41467-023-36681-z

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