Genomic attributes of Vibrio cholerae O1 responsible for 2022 massive cholera outbreak in Bangladesh

Md Mamun Monir, Mohammad Tarequl Islam, Razib Mazumder, Dinesh Mondal, Kazi Sumaita Nahar, Marzia Sultana, Masatomo Morita, Makoto Ohnishi, Anwar Huq, Haruo Watanabe, Firdausi Qadri, Mustafizur Rahman, Nicholas Thomson, Kimberley Seed, Rita R. Colwell, Tahmeed Ahmed and Munirul Alam ()
Additional contact information
Md Mamun Monir: Infectious diseases division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh)
Mohammad Tarequl Islam: Infectious diseases division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh)
Razib Mazumder: Laboratory Sciences and Services Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh)
Dinesh Mondal: Laboratory Sciences and Services Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh)
Kazi Sumaita Nahar: Infectious diseases division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh)
Marzia Sultana: Infectious diseases division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh)
Masatomo Morita: National Institute of Infectious Diseases (NIID)
Makoto Ohnishi: National Institute of Infectious Diseases (NIID)
Anwar Huq: University of Maryland
Haruo Watanabe: National Institute of Infectious Diseases (NIID)
Firdausi Qadri: Infectious diseases division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh)
Mustafizur Rahman: Infectious diseases division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh)
Nicholas Thomson: Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus
Kimberley Seed: University of California
Rita R. Colwell: University of Maryland
Tahmeed Ahmed: Nutrition and Clinical Services Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh)
Munirul Alam: Infectious diseases division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh)

Nature Communications, 2023, vol. 14, issue 1, 1-8

Abstract: Abstract In 2022, one of its worst cholera outbreaks began in Bangladesh and the icddr,b Dhaka hospital treated more than 1300 patients and ca. 42,000 diarrheal cases from March-1 to April-10, 20221. Here, we present genomic attributes of V. cholerae O1 responsible for the 2022 Dhaka outbreak and 960 7th pandemic El Tor (7PET) strains from 88 countries. Results show strains isolated during the Dhaka outbreak cluster with 7PET wave-3 global clade strains, but comprise subclade BD-1.2, for which the most recent common ancestor appears to be that responsible for recent endemic cholera in India. BD-1.2 strains are present in Bangladesh since 2016, but not establishing dominance over BD-2 lineage strains2 until 2018 and predominantly associated with endemic cholera. In conclusion, the recent shift in lineage and genetic attributes, including serotype switching of BD-1.2 from Ogawa to Inaba, may explain the increasing number of cholera cases in Bangladesh.

Date: 2023
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DOI: 10.1038/s41467-023-36687-7

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