Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions

Amit Rimon, Chani Rakov, Vanda Lerer, Sivan Sheffer-Levi, Sivan Alkalay Oren, Tehila Shlomov, Lihi Shasha, Ruth Lubin, Khaled Zubeidat, Nora Jaber, Musa Mujahed, Asaf Wilensky, Shunit Coppenhagen-Glazer, Vered Molho-Pessach and Ronen Hazan ()
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Amit Rimon: The Hebrew University of Jerusalem
Chani Rakov: The Hebrew University of Jerusalem
Vanda Lerer: The Hebrew University of Jerusalem
Sivan Sheffer-Levi: The Hebrew University of Jerusalem
Sivan Alkalay Oren: The Hebrew University of Jerusalem
Tehila Shlomov: The Hebrew University of Jerusalem
Lihi Shasha: The Hebrew University of Jerusalem
Ruth Lubin: The Hebrew University of Jerusalem
Khaled Zubeidat: The Hebrew University of Jerusalem
Nora Jaber: The Hebrew University of Jerusalem
Musa Mujahed: The Hebrew University of Jerusalem
Asaf Wilensky: The Hebrew University of Jerusalem
Shunit Coppenhagen-Glazer: The Hebrew University of Jerusalem
Vered Molho-Pessach: The Hebrew University of Jerusalem
Ronen Hazan: The Hebrew University of Jerusalem

Nature Communications, 2023, vol. 14, issue 1, 1-18

Abstract: Abstract Acne vulgaris is a common neutrophil-driven inflammatory skin disorder in which Cutibacterium acnes (C. acnes) is known to play a key role. For decades, antibiotics have been widely employed to treat acne vulgaris, inevitably resulting in increased bacterial antibiotic resistance. Phage therapy is a promising strategy to combat the growing challenge of antibiotic-resistant bacteria, utilizing viruses that specifically lyse bacteria. Herein, we explore the feasibility of phage therapy against C. acnes. Eight novel phages, isolated in our laboratory, and commonly used antibiotics eradicate 100% of clinically isolated C. acnes strains. Topical phage therapy in a C. acnes-induced acne-like lesions mouse model affords significantly superior clinical and histological scores. Moreover, the decrease in inflammatory response was reflected by the reduced expression of chemokine CXCL2, neutrophil infiltration, and other inflammatory cytokines when compared with the infected-untreated group. Overall, these findings indicate the potential of phage therapy for acne vulgaris as an additional tool to conventional antibiotics.

Date: 2023
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DOI: 10.1038/s41467-023-36694-8

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