Extracting particle size distribution from laser speckle with a physics-enhanced autocorrelation-based estimator (PEACE)

Qihang Zhang, Janaka C. Gamekkanda, Ajinkya Pandit, Wenlong Tang, Charles Papageorgiou, Chris Mitchell, Yihui Yang, Michael Schwaerzler, Tolutola Oyetunde, Richard D. Braatz, Allan S. Myerson and George Barbastathis ()
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Qihang Zhang: Massachusetts Institute of Technology
Janaka C. Gamekkanda: Massachusetts Institute of Technology
Ajinkya Pandit: Massachusetts Institute of Technology
Wenlong Tang: Takeda Pharmaceuticals International Co
Charles Papageorgiou: Takeda Pharmaceuticals International Co
Chris Mitchell: Takeda Pharmaceuticals International Co
Yihui Yang: Takeda Pharmaceuticals International Co
Michael Schwaerzler: Takeda Pharmaceutical Company Limited
Tolutola Oyetunde: Takeda Pharmaceutical Company Limited
Richard D. Braatz: Massachusetts Institute of Technology
Allan S. Myerson: Massachusetts Institute of Technology
George Barbastathis: Massachusetts Institute of Technology

Nature Communications, 2023, vol. 14, issue 1, 1-9

Abstract: Abstract Extracting quantitative information about highly scattering surfaces from an imaging system is challenging because the phase of the scattered light undergoes multiple folds upon propagation, resulting in complex speckle patterns. One specific application is the drying of wet powders in the pharmaceutical industry, where quantifying the particle size distribution (PSD) is of particular interest. A non-invasive and real-time monitoring probe in the drying process is required, but there is no suitable candidate for this purpose. In this report, we develop a theoretical relationship from the PSD to the speckle image and describe a physics-enhanced autocorrelation-based estimator (PEACE) machine learning algorithm for speckle analysis to measure the PSD of a powder surface. This method solves both the forward and inverse problems together and enjoys increased interpretability, since the machine learning approximator is regularized by the physical law.

Date: 2023
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DOI: 10.1038/s41467-023-36816-2

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