Antigen discrimination by T cells relies on size-constrained microvillar contact

Edward Jenkins, Markus Körbel, Caitlin O’Brien-Ball, James McColl, Kevin Y. Chen, Mateusz Kotowski, Jane Humphrey, Anna H. Lippert, Heather Brouwer, Ana Mafalda Santos, Steven F. Lee, Simon J. Davis () and David Klenerman ()
Additional contact information
Edward Jenkins: University of Oxford
Markus Körbel: University of Cambridge
Caitlin O’Brien-Ball: University of Oxford
James McColl: University of Cambridge
Kevin Y. Chen: University of Cambridge
Mateusz Kotowski: University of Oxford
Jane Humphrey: University of Cambridge
Anna H. Lippert: University of Cambridge
Heather Brouwer: University of Oxford
Ana Mafalda Santos: University of Oxford
Steven F. Lee: University of Cambridge
Simon J. Davis: University of Oxford
David Klenerman: University of Cambridge

Nature Communications, 2023, vol. 14, issue 1, 1-21

Abstract: Abstract T cells use finger-like protrusions called ‘microvilli’ to interrogate their targets, but why they do so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer of large molecules forming a target cell’s glycocalyx. Here, T cells are observed to use microvilli to breach a model glycocalyx barrier, forming numerous small (

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36855-9

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DOI: 10.1038/s41467-023-36855-9

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