Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251

Jeffy G. Mattathil, Asisa Volz, Olusegun O. Onabajo, Sean Maynard, Sandra L. Bixler, Xiaoying X. Shen, Diego Vargas-Inchaustegui, Marjorie Robert-Guroff, Celia Lebranche, Georgia Tomaras, David Montefiori, Gerd Sutter and Joseph J. Mattapallil ()
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Jeffy G. Mattathil: Henry M. Jackson Foundation for Military Medicine
Asisa Volz: University of Veterinary Medicine Hannover
Olusegun O. Onabajo: Henry M. Jackson Foundation for Military Medicine
Sean Maynard: Henry M. Jackson Foundation for Military Medicine
Sandra L. Bixler: Henry M. Jackson Foundation for Military Medicine
Xiaoying X. Shen: Duke University School of Medicine
Diego Vargas-Inchaustegui: National Cancer Institute
Marjorie Robert-Guroff: National Cancer Institute
Celia Lebranche: Duke University School of Medicine
Georgia Tomaras: Duke University School of Medicine
David Montefiori: Duke University School of Medicine
Gerd Sutter: Division of Virology, Department of Veterinary Sciences, LMU
Joseph J. Mattapallil: Department of Microbiology and Immunology, Uniformed Services University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Human immunodeficiency virus (HIV) is a mucosally transmitted virus that causes immunodeficiency and AIDS. Developing efficacious vaccines to prevent infection is essential to control the epidemic. Protecting the vaginal and rectal mucosa, the primary routes of HIV entry has been a challenge given the significant compartmentalization between the mucosal and peripheral immune systems. We hypothesized that direct intranodal vaccination of mucosa associated lymphoid tissue (MALT) such as the readily accessible palatine tonsils could overcome this compartmentalization. Here we show that rhesus macaques primed with plasmid DNA encoding SIVmac251-env and gag genes followed by an intranodal tonsil MALT boost with MVA encoding the same genes protects from a repeated low dose intrarectal challenge with highly pathogenic SIVmac251; 43% (3/7) of vaccinated macaques remained uninfected after 9 challenges as compared to the unvaccinated control (0/6) animals. One vaccinated animal remained free of infection even after 22 challenges. Vaccination was associated with a ~2 log decrease in acute viremia that inversely correlated with anamnestic immune responses. Our results suggest that a combination of systemic and intranodal tonsil MALT vaccination could induce robust adaptive and innate immune responses leading to protection from mucosal infection with highly pathogenic HIV and rapidly control viral breakthroughs.

Date: 2023
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DOI: 10.1038/s41467-023-36907-0

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