Beta variant COVID-19 protein booster vaccine elicits durable cross-neutralization against SARS-CoV-2 variants in non-human primates

Vincent Pavot, Catherine Berry, Michael Kishko, Natalie G. Anosova, Lu Li, Tim Tibbitts, Dean Huang, Alice Raillard, Sylviane Gautheron, Cindy Gutzeit, Marguerite Koutsoukos, Roman M. Chicz and Valerie Lecouturier ()
Additional contact information
Vincent Pavot: Sanofi
Catherine Berry: Sanofi
Michael Kishko: Sanofi
Natalie G. Anosova: Sanofi
Lu Li: Sanofi
Tim Tibbitts: Sanofi
Dean Huang: Sanofi
Alice Raillard: Sanofi
Sylviane Gautheron: Sanofi
Cindy Gutzeit: GSK
Marguerite Koutsoukos: GSK
Roman M. Chicz: Sanofi
Valerie Lecouturier: Sanofi

Nature Communications, 2023, vol. 14, issue 1, 1-8

Abstract: Abstract The rapid spread of the SARS-CoV-2 Omicron subvariants, despite the implementation of booster vaccination, has raised questions about the durability of protection conferred by current vaccines. Vaccine boosters that can induce broader and more durable immune responses against SARS-CoV-2 are urgently needed. We recently reported that our Beta-containing protein-based SARS-CoV-2 spike booster vaccine candidates with AS03 adjuvant (CoV2 preS dTM-AS03) elicited robust cross-neutralizing antibody responses at early timepoints against SARS-CoV-2 variants of concern in macaques primed with mRNA or protein-based subunit vaccine candidates. Here we demonstrate that the monovalent Beta vaccine with AS03 adjuvant induces durable cross-neutralizing antibody responses against the prototype strain D614G as well as variants Delta (B.1.617.2), Omicron (BA.1 and BA.4/5) and SARS-CoV-1, that are still detectable in all macaques 6 months post-booster. We also describe the induction of consistent and robust memory B cell responses, independent of the levels measured post-primary immunization. These data suggest that a booster dose with a monovalent Beta CoV2 preS dTM-AS03 vaccine can induce robust and durable cross-neutralizing responses against a broad spectrum of variants.

Date: 2023
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DOI: 10.1038/s41467-023-36908-z

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