A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus

Michael H. Berry, Michael Moldavan, Tavita Garrett, Marc Meadows, Olga Cravetchi, Elizabeth White, Joseph Leffler, Henrique Gersdorff, Kevin M. Wright, Charles N. Allen and Benjamin Sivyer ()
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Michael H. Berry: Oregon Health & Science University
Michael Moldavan: Oregon Health and Science University
Tavita Garrett: Oregon Health & Science University
Marc Meadows: Oregon Health & Science University
Olga Cravetchi: Oregon Health and Science University
Elizabeth White: Oregon Health & Science University
Joseph Leffler: Oregon Health & Science University
Henrique Gersdorff: Oregon Health & Science University
Kevin M. Wright: Oregon Health & Science University
Charles N. Allen: Oregon Health and Science University
Benjamin Sivyer: Oregon Health & Science University

Nature Communications, 2023, vol. 14, issue 1, 1-19

Abstract: Abstract Visual input to the hypothalamus from intrinsically photosensitive retinal ganglion cells (ipRGCs) influences several functions including circadian entrainment, body temperature, and sleep. ipRGCs also project to nuclei such as the supraoptic nucleus (SON), which is involved in systemic fluid homeostasis, maternal behavior, social behaviors, and appetite. However, little is known about the SON-projecting ipRGCs or their relationship to well-characterized ipRGC subtypes. Using a GlyT2Cre mouse line, we show a subtype of ipRGCs restricted to the dorsal retina that selectively projects to the SON. These ipRGCs tile a dorsal region of the retina, forming a substrate for encoding ground luminance. Optogenetic activation of their axons demonstrates they release the neurotransmitter glutamate in multiple regions, including the suprachiasmatic nucleus (SCN) and SON. Our results challenge the idea that ipRGC dendrites overlap to optimize photon capture and suggests non-image forming vision operates to sample local regions of the visual field to influence diverse behaviors.

Date: 2023
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DOI: 10.1038/s41467-023-36955-6

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