A rare human variant that disrupts GPR10 signalling causes weight gain in mice

Fleur Talbot, Claire H. Feetham, Jacek Mokrosiński, Katherine Lawler, Julia M. Keogh, Elana Henning, Edson Mendes de Oliveira, Vikram Ayinampudi, Sadia Saeed, Amélie Bonnefond, Mohammed Arslan, Giles S. H. Yeo, Philippe Froguel, David A. Bechtold, Antony Adamson, Neil Humphreys, Inês Barroso, Simon M. Luckman () and I. Sadaf Farooqi ()
Additional contact information
Fleur Talbot: Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Claire H. Feetham: Faculty of Biology, Medicine and Health, University of Manchester
Jacek Mokrosiński: Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Katherine Lawler: Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Julia M. Keogh: Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Elana Henning: Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Edson Mendes de Oliveira: Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Vikram Ayinampudi: Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Sadia Saeed: Digestion and Reproduction, Imperial College London
Amélie Bonnefond: Digestion and Reproduction, Imperial College London
Mohammed Arslan: Forman Christian College
Giles S. H. Yeo: Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Philippe Froguel: Digestion and Reproduction, Imperial College London
David A. Bechtold: Faculty of Biology, Medicine and Health, University of Manchester
Antony Adamson: Medicine and Health, University of Manchester
Neil Humphreys: Medicine and Health, University of Manchester
Inês Barroso: Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
Simon M. Luckman: Faculty of Biology, Medicine and Health, University of Manchester
I. Sadaf Farooqi: Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract Disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These variants impair ligand binding and G protein-dependent signalling in cells. Transgenic mice harbouring a loss of function GPR10 variant found in an individual with obesity, gain excessive weight due to decreased energy expenditure rather than increased food intake. This evidence supports a role for GPR10 in human energy homeostasis. Therapeutic targeting of GPR10 may represent an effective weight-loss strategy.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-36966-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36966-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-36966-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().