Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers

Ulrika Marking, Sebastian Havervall, Nina Greilert Norin, Oscar Bladh, Wanda Christ, Max Gordon, Henry Ng, Kim Blom, Mia Phillipson, Sara Mangsbo, Jessica J. Alm, Anna Smed-Sörensen, Peter Nilsson, Sophia Hober, Mikael Åberg, Jonas Klingström and Charlotte Thålin ()
Additional contact information
Ulrika Marking: Karolinska Institutet Danderyd Hospital
Sebastian Havervall: Karolinska Institutet Danderyd Hospital
Nina Greilert Norin: Karolinska Institutet Danderyd Hospital
Oscar Bladh: Karolinska Institutet Danderyd Hospital
Wanda Christ: Karolinska Institutet
Max Gordon: Karolinska Institutet Danderyd Hospital
Henry Ng: Uppsala University
Kim Blom: Karolinska Institutet Danderyd Hospital
Mia Phillipson: Uppsala University
Sara Mangsbo: Uppsala University
Jessica J. Alm: Karolinska Institutet
Anna Smed-Sörensen: Karolinska Institutet, Karolinska University Hospital
Peter Nilsson: KTH Royal Institute of Technology, SciLifeLab
Sophia Hober: KTH Royal Institute of Technology, SciLifeLab
Mikael Åberg: Uppsala University
Jonas Klingström: Karolinska Institutet
Charlotte Thålin: Karolinska Institutet Danderyd Hospital

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract Vaccination offers protection against severe COVID-19 caused by SARS-CoV-2 omicron but is less effective against infection. Characteristics such as serum antibody titer correlation to protection, viral abundance and clearance of omicron infection in vaccinated individuals are scarce. We present a 4-week twice-weekly SARS-CoV-2 qPCR screening in 368 triple vaccinated healthcare workers. Spike-specific IgG levels, neutralization titers and mucosal spike-specific IgA-levels were determined at study start and qPCR-positive participants were sampled repeatedly for two weeks. 81 (cumulative incidence 22%) BA.1, BA.1.1 and BA.2 infections were detected. High serum antibody titers are shown to be protective against infection (p

Date: 2023
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DOI: 10.1038/s41467-023-36984-1

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