Microbiota alters the metabolome in an age- and sex- dependent manner in mice

Kirsty Brown, Carolyn A. Thomson, Soren Wacker, Marija Drikic, Ryan Groves, Vina Fan, Ian A. Lewis and Kathy D. McCoy ()
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Kirsty Brown: University of Calgary
Carolyn A. Thomson: University of Calgary
Soren Wacker: University of Calgary
Marija Drikic: University of Calgary
Ryan Groves: University of Calgary
Vina Fan: University of Calgary
Ian A. Lewis: University of Calgary
Kathy D. McCoy: University of Calgary

Nature Communications, 2023, vol. 14, issue 1, 1-12

Abstract: Abstract Commensal bacteria are major contributors to mammalian metabolism. We used liquid chromatography mass spectrometry to study the metabolomes of germ-free, gnotobiotic, and specific-pathogen-free mice, while also evaluating the influence of age and sex on metabolite profiles. Microbiota modified the metabolome of all body sites and accounted for the highest proportion of variation within the gastrointestinal tract. Microbiota and age explained similar amounts of variation the metabolome of urine, serum, and peritoneal fluid, while age was the primary driver of variation in the liver and spleen. Although sex explained the least amount of variation at all sites, it had a significant impact on all sites except the ileum. Collectively, these data illustrate the interplay between microbiota, age, and sex in the metabolic phenotypes of diverse body sites. This provides a framework for interpreting complex metabolic phenotypes and will help guide future studies into the role that the microbiome plays in disease.

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37055-1

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DOI: 10.1038/s41467-023-37055-1

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