Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates

Ryuta Uraki, Shun Iida, Peter J. Halfmann, Seiya Yamayoshi, Yuichiro Hirata, Kiyoko Iwatsuki-Horimoto, Maki Kiso, Mutsumi Ito, Yuri Furusawa, Hiroshi Ueki, Yuko Sakai-Tagawa, Makoto Kuroda, Tadashi Maemura, Taksoo Kim, Sohtaro Mine, Noriko Iwamoto, Rong Li, Yanan Liu, Deanna Larson, Shuetsu Fukushi, Shinji Watanabe, Ken Maeda, Zhongde Wang, Norio Ohmagari, James Theiler, Will Fischer, Bette Korber (), Masaki Imai (), Tadaki Suzuki () and Yoshihiro Kawaoka ()
Additional contact information
Ryuta Uraki: University of Tokyo
Shun Iida: National Institute of Infectious Diseases
Peter J. Halfmann: University of Wisconsin-Madison
Seiya Yamayoshi: University of Tokyo
Yuichiro Hirata: National Institute of Infectious Diseases
Kiyoko Iwatsuki-Horimoto: University of Tokyo
Maki Kiso: University of Tokyo
Mutsumi Ito: University of Tokyo
Yuri Furusawa: University of Tokyo
Hiroshi Ueki: University of Tokyo
Yuko Sakai-Tagawa: University of Tokyo
Makoto Kuroda: University of Wisconsin-Madison
Tadashi Maemura: University of Wisconsin-Madison
Taksoo Kim: University of Wisconsin-Madison
Sohtaro Mine: National Institute of Infectious Diseases
Noriko Iwamoto: National Center for Global Health and Medicine Hospital
Rong Li: Utah State University
Yanan Liu: Utah State University
Deanna Larson: Utah State University
Shuetsu Fukushi: National Institute of Infectious Diseases
Shinji Watanabe: National Institute of Infectious Diseases
Ken Maeda: National Institute of Infectious Diseases
Zhongde Wang: Utah State University
Norio Ohmagari: National Center for Global Health and Medicine Hospital
James Theiler: Los Alamos National Laboratory
Will Fischer: Los Alamos National Laboratory
Bette Korber: Los Alamos National Laboratory
Masaki Imai: University of Tokyo
Tadaki Suzuki: National Institute of Infectious Diseases
Yoshihiro Kawaoka: University of Tokyo

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract The prevalence of the Omicron subvariant BA.2.75 rapidly increased in India and Nepal during the summer of 2022, and spread globally. However, the virological features of BA.2.75 are largely unknown. Here, we evaluated the replicative ability and pathogenicity of BA.2.75 clinical isolates in Syrian hamsters. Although we found no substantial differences in weight change among hamsters infected with BA.2, BA.5, or BA.2.75, the replicative ability of BA.2.75 in the lungs is higher than that of BA.2 and BA.5. Of note, BA.2.75 causes focal viral pneumonia in hamsters, characterized by patchy inflammation interspersed in alveolar regions, which is not observed in BA.5-infected hamsters. Moreover, in competition assays, BA.2.75 replicates better than BA.5 in the lungs of hamsters. These results suggest that BA.2.75 can cause more severe respiratory disease than BA.5 and BA.2 in a hamster model and should be closely monitored.

Date: 2023
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DOI: 10.1038/s41467-023-37059-x

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