Wavelength engineerable porous organic polymer photosensitizers with protonation triggered ROS generation

Jinwoo Shin, Dong Won Kang, Jong Hyeon Lim, Jong Min An, Youngseo Kim, Ji Hyeon Kim, Myung Sun Ji, Sungnam Park (), Dokyoung Kim (), Jin Yong Lee (), Jong Seung Kim () and Chang Seop Hong ()
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Jinwoo Shin: Korea University
Dong Won Kang: Korea University
Jong Hyeon Lim: Sungkyunkwan University
Jong Min An: Kyung Hee University
Youngseo Kim: Korea University
Ji Hyeon Kim: Korea University
Myung Sun Ji: Korea University
Sungnam Park: Korea University
Dokyoung Kim: Kyung Hee University
Jin Yong Lee: Sungkyunkwan University
Jong Seung Kim: Korea University
Chang Seop Hong: Korea University

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Engineering excitation wavelength of photosensitizers (PSs) for enhanced reactive oxygen species (ROS) generation has inspired new windows for opportunities, enabling investigation of previously impracticable biomedical and photocatalytic applications. However, controlling the wavelength corresponding to operating conditions remains challenging while maintaining high ROS generation. To address this challenge, we implement a wavelength-engineerable imidazolium-based porous organic photocatalytic ROS generation system (KUP system) via a cost-effective one-pot reaction. Remarkably, the optimal wavelength for maximum performance can be tuned by modifying the linker, generating ROS despite the absence of metal ions and covalently attached heavy atoms. We demonstrate that protonated polymerization exclusively enables photosensitization and closely interacts with oxygen related to the efficiency of photosensitizing. Furthermore, superior tumor eradication and biocompatibility of the KUP system were confirmed through bioassays. Overall, the results document an unprecedented polymerization method capable of engineering wavelength, providing a potential basis for designing nanoscale photosensitizers in various ROS-utilizing applications.

Date: 2023
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DOI: 10.1038/s41467-023-37156-x

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