Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts

Ayodeji Adegunsoye (), Chad A. Newton, Justin M. Oldham, Brett Ley, Cathryn T. Lee, Angela L. Linderholm, Jonathan H. Chung, Nicole Garcia, Da Zhang, Rekha Vij, Robert Guzy, Renea Jablonski, Remzi Bag, Rebecca S. Voogt, Shwu-Fan Ma, Anne I. Sperling, Ganesh Raghu, Fernando J. Martinez, Mary E. Strek, Paul J. Wolters, Christine Kim Garcia, Brandon L. Pierce and Imre Noth
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Ayodeji Adegunsoye: The University of Chicago
Chad A. Newton: University of Texas Southwestern
Justin M. Oldham: University of California, Davis
Brett Ley: University of California
Cathryn T. Lee: The University of Chicago
Angela L. Linderholm: University of California, Davis
Jonathan H. Chung: The University of Chicago
Nicole Garcia: The University of Chicago
Da Zhang: Columbia University Medical Center
Rekha Vij: The University of Chicago
Robert Guzy: The University of Chicago
Renea Jablonski: The University of Chicago
Remzi Bag: The University of Chicago
Rebecca S. Voogt: The University of Chicago
Shwu-Fan Ma: University of Virginia
Anne I. Sperling: The University of Chicago
Ganesh Raghu: University of Washington Medical Center
Fernando J. Martinez: Weill Cornell Medicine
Mary E. Strek: The University of Chicago
Paul J. Wolters: University of California
Christine Kim Garcia: Columbia University Medical Center
Brandon L. Pierce: The University of Chicago
Imre Noth: University of Virginia

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Pulmonary fibrosis (PF) is characterized by profound scarring and poor survival. We investigated the association of leukocyte telomere length (LTL) with chronological age and mortality across racially diverse PF cohorts. LTL measurements among participants with PF stratified by race/ethnicity were assessed in relation to age and all-cause mortality, and compared to controls. Generalized linear models were used to evaluate the age-LTL relationship, Cox proportional hazards models were used for hazard ratio estimation, and the Cochran–Armitage test was used to assess quartiles of LTL. Standardized LTL shortened with increasing chronological age; this association in controls was strengthened in PF (R = −0.28; P

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37193-6

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DOI: 10.1038/s41467-023-37193-6

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