The genomic epidemiology of Escherichia albertii infecting humans and birds in Great Britain

Rebecca J. Bengtsson, Kate S. Baker (), Andrew A. Cunningham, David R. Greig, Shinto K. John, Shaheed K. Macgregor, Katharina Seilern-Moy, Simon Spiro, Charlotte C. Chong, P Malaka De Silva, Claire Jenkins and Becki Lawson
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Rebecca J. Bengtsson: The University of Liverpool
Kate S. Baker: The University of Liverpool
Andrew A. Cunningham: Zoological Society of London, Regent’s Park
David R. Greig: Gastrointestinal and Food Safety (One Health) Division, UK Health Security Agency, Colindale
Shinto K. John: Zoological Society of London, Regent’s Park
Shaheed K. Macgregor: Zoological Society of London, Regent’s Park
Katharina Seilern-Moy: Zoological Society of London, Regent’s Park
Simon Spiro: Zoological Society of London, Regent’s Park
Charlotte C. Chong: The University of Liverpool
P Malaka De Silva: The University of Liverpool
Claire Jenkins: Gastrointestinal and Food Safety (One Health) Division, UK Health Security Agency, Colindale
Becki Lawson: Zoological Society of London, Regent’s Park

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Escherichia albertii is a recently identified gastrointestinal bacterial pathogen of humans and animals which is typically misidentified as pathotypes of diarrhoeagenic Escherichia coli or Shigella species and is generally only detected during genomic surveillance of other Enterobacteriaceae. The incidence of E. albertii is likely underestimated, and its epidemiology and clinical relevance are poorly characterised. Here, we whole genome sequenced E. albertii isolates from humans (n = 83) and birds (n = 79) isolated in Great Britain between 2000 and 2021 and analysed these alongside a broader public dataset (n = 475) to address these gaps. We found human and avian isolates typically (90%; 148/164) belonged to host-associated monophyletic groups with distinct virulence and antimicrobial resistance profiles. Overlaid patient epidemiological data suggested that human infection was likely related to travel and possibly foodborne transmission. The Shiga toxin encoding stx2f gene was associated with clinical disease (OR = 10.27, 95% CI = 2.98–35.45 p = 0.0002) in finches. Our results suggest that improved future surveillance will further elucidate disease ecology and public and animal health risks associated with E. albertii.

Date: 2023
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DOI: 10.1038/s41467-023-37312-3

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