Purkinje cell dopaminergic inputs to astrocytes regulate cerebellar-dependent behavior

Chang Li, Natalie B. Saliba, Hannah Martin, Nicole A. Losurdo, Kian Kolahdouzan, Riyan Siddiqui, Destynie Medeiros and Wei Li ()
Additional contact information
Chang Li: University of Alabama at Birmingham
Natalie B. Saliba: University of Alabama at Birmingham
Hannah Martin: University of Alabama at Birmingham
Nicole A. Losurdo: University of Alabama at Birmingham
Kian Kolahdouzan: University of Alabama at Birmingham
Riyan Siddiqui: University of Alabama at Birmingham
Destynie Medeiros: University of Alabama at Birmingham
Wei Li: University of Alabama at Birmingham

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract Dopamine has a significant role in motor and cognitive function. The dopaminergic pathways originating from the midbrain have received the most attention; however, the relevance of the cerebellar dopaminergic system is largely undiscovered. Here, we show that the major cerebellar astrocyte type Bergmann glial cells express D1 receptors. Dopamine can be synthesized in Purkinje cells by cytochrome P450 and released in an activity-dependent fashion. We demonstrate that activation of D1 receptors induces membrane depolarization and Ca2+ release from the internal store. These astrocytic activities in turn modify Purkinje cell output by altering its excitatory and inhibitory synaptic input. Lastly, we show that conditional knockout of D1 receptors in Bergmann glial cells results in decreased locomotor activity and impaired social activity. These results contribute to the understanding of the molecular, cellular, and circuit mechanisms underlying dopamine function in the cerebellum, revealing a critical role for the cerebellar dopaminergic system in motor and social behavior.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-37319-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37319-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-37319-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().