Bacterial outer membrane vesicle based versatile nanosystem boosts the efferocytosis blockade triggered tumor-specific immunity

Wan-Ru Zhuang, Yunfeng Wang, Weidong Nie, Yao Lei, Chao Liang, Jiaqi He, Liping Zuo, Li-Li Huang and Hai-Yan Xie ()
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Wan-Ru Zhuang: Beijing Institute of Technology
Yunfeng Wang: Beijing Institute of Technology
Weidong Nie: Beijing Institute of Technology
Yao Lei: Beijing Institute of Technology
Chao Liang: Beijing Institute of Technology
Jiaqi He: Beijing Institute of Technology
Liping Zuo: Beijing Institute of Technology
Li-Li Huang: Beijing Institute of Technology
Hai-Yan Xie: Beijing Institute of Technology

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Efferocytosis inhibition is emerging as an attractive strategy for antitumor immune therapy because of the subsequent leak of abundant immunogenic contents. However, the practical efficacy is seriously impeded by the immunosuppressive tumor microenvironments. Here, we construct a versatile nanosystem that can not only inhibit the efferocytosis but also boost the following antitumor immunity. MerTK inhibitor UNC2025 is loaded into the bacterial outer membrane vesicles (OMVs), which are then modified with maleimide (mU@OMVs). The prepared mU@OMVs effectively inhibits the efferocytosis by promoting the uptake while preventing the MerTK phosphorylation of tumor associated macrophages, and then captures the released antigens through forming universal thioether bonds. The obtained in situ vaccine effectively transfers to lymph nodes by virtue of the intrinsic features of OMVs, and then provokes intense immune responses that can efficiently prevent the growth, metastasis and recurrence of tumors in mice, providing a generalizable strategy for cancer immunotherapy.

Date: 2023
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DOI: 10.1038/s41467-023-37369-0

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