Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry

Kanako Watanabe, Tomoichiro Oka, Hirotaka Takagi, Sergei Anisimov, Shun-ichi Yamashita, Yoshinori Katsuragi, Masahiko Takahashi, Masaya Higuchi, Tomotake Kanki, Akihiko Saitoh and Masahiro Fujii ()
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Kanako Watanabe: Niigata University Graduate School of Health Sciences
Tomoichiro Oka: National Institute of Infectious Diseases
Hirotaka Takagi: National Institute of Infectious Diseases
Sergei Anisimov: Niigata University Graduate School of Medical and Dental Sciences
Shun-ichi Yamashita: Niigata University Graduate School of Medical and Dental Sciences
Yoshinori Katsuragi: Niigata College of Nursing
Masahiko Takahashi: Niigata University Graduate School of Medical and Dental Sciences
Masaya Higuchi: Kanazawa Medical University School of Medicine
Tomotake Kanki: Niigata University Graduate School of Medical and Dental Sciences
Akihiko Saitoh: Niigata University Graduate School of Medical and Dental Sciences
Masahiro Fujii: Niigata University Graduate School of Medical and Dental Sciences

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Human parechovirus (PeV-A) is an RNA virus that belongs to the family Picornaviridae and it is currently classified into 19 genotypes. PeV-As usually cause mild illness in children and adults. Among the genotypes, PeV-A3 can cause severe diseases in neonates and young infants, resulting in neurological sequelae and death. In this study, we identify the human myeloid-associated differentiation marker (MYADM) as an essential host factor for the entry of six PeV-As (PeV-A1 to PeV-A6), including PeV-A3. The infection of six PeV-As (PeV-A1 to PeV-A6) to human cells is abolished by knocking out the expression of MYADM. Hamster BHK-21 cells are resistant to PeV-A infection, but the expression of human MYADM in BHK-21 confers PeV-A infection and viral production. Furthermore, VP0 capsid protein of PeV-A3 interacts with one extracellular domain of human MYADM on the cell membrane of BHK-21. The identification of MYADM as an essential entry factor for PeV-As infection is expected to advance our understanding of the pathogenesis of PeV-As.

Date: 2023
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DOI: 10.1038/s41467-023-37399-8

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