Neuraminidase 1 promotes renal fibrosis development in male mice

Qian-Qian Chen, Kang Liu, Ning Shi, Gaoxiang Ma, Peipei Wang, Hua-Mei Xie, Si-Jia Jin, Ting-Ting Wei, Xiang-Yu Yu, Yi Wang, Jun-Yuan Zhang, Ping Li, Lian-Wen Qi () and Lei Zhang ()
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Qian-Qian Chen: China Pharmaceutical University
Kang Liu: The First Affiliated Hospital of Nanjing Medical University
Ning Shi: China Pharmaceutical University
Gaoxiang Ma: China Pharmaceutical University
Peipei Wang: Shanghai Ocean University
Hua-Mei Xie: China Pharmaceutical University
Si-Jia Jin: China Pharmaceutical University
Ting-Ting Wei: China Pharmaceutical University
Xiang-Yu Yu: China Pharmaceutical University
Yi Wang: China Pharmaceutical University
Jun-Yuan Zhang: China Pharmaceutical University
Ping Li: China Pharmaceutical University
Lian-Wen Qi: China Pharmaceutical University
Lei Zhang: China Pharmaceutical University

Nature Communications, 2023, vol. 14, issue 1, 1-20

Abstract: Abstract The functions of the influenza virus neuraminidase has been well documented but those of the mammalian neuraminidases remain less explored. Here, we characterize the role of neuraminidase 1 (NEU1) in unilateral ureteral obstruction (UUO) and folic acid (FA)-induced renal fibrosis mouse models. We find that NEU1 is significantly upregulated in the fibrotic kidneys of patients and mice. Functionally, tubular epithelial cell-specific NEU1 knockout inhibits epithelial-to-mesenchymal transition, inflammatory cytokines production, and collagen deposition in mice. Conversely, NEU1 overexpression exacerbates progressive renal fibrosis. Mechanistically, NEU1 interacts with TGFβ type I receptor ALK5 at the 160-200aa region and stabilizes ALK5 leading to SMAD2/3 activation. Salvianolic acid B, a component of Salvia miltiorrhiza, is found to strongly bind to NEU1 and effectively protect mice from renal fibrosis in a NEU1-dependent manner. Collectively, this study characterizes a promotor role for NEU1 in renal fibrosis and suggests a potential avenue of targeting NEU1 to treat kidney diseases.

Date: 2023
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DOI: 10.1038/s41467-023-37450-8

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