Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype

Xin-Hua Wu, Yang-Yang He, Zhang-Rong Chen, Ze-Yuan He, Yi Yan, Yangzhige He, Guang-Ming Wang, Yu Dong, Ying Yang, Yi-Min Sun, Yong-Hong Ren, Qiu-Yan Zhao, Xiao-Dan Yang, Li-Ying Wang, Cai-Jun Fu, Miao He, Si-Jin Zhang, Ji-Fen Fu, Hong Liu () and Zhi-Cheng Jing ()
Additional contact information
Xin-Hua Wu: The First Affiliated Hospital of Dali University
Yang-Yang He: Henan University
Zhang-Rong Chen: The First Affiliated Hospital of Dali University
Ze-Yuan He: Yulong People’s Hospital
Yi Yan: Shanghai Jiao Tong University School of Medicine
Yangzhige He: Chinese Academy of Medical Sciences & Peking Union Medical College
Guang-Ming Wang: The First Affiliated Hospital of Dali University
Yu Dong: The First Affiliated Hospital of Dali University
Ying Yang: The First Affiliated Hospital of Dali University
Yi-Min Sun: CapitalBio Technology Corporation
Yong-Hong Ren: CapitalBio Technology Corporation
Qiu-Yan Zhao: The First Affiliated Hospital of Dali University
Xiao-Dan Yang: The First Affiliated Hospital of Dali University
Li-Ying Wang: The First Affiliated Hospital of Dali University
Cai-Jun Fu: The First Affiliated Hospital of Dali University
Miao He: Dali University
Si-Jin Zhang: Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Ji-Fen Fu: The First Affiliated Hospital of Dali University
Hong Liu: The First Affiliated Hospital of Dali University
Zhi-Cheng Jing: Chinese Academy of Medical Sciences & Peking Union Medical College

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Immune and inflammatory responses have an important function in the pathophysiology of pulmonary hypertension (PH). However, little is known about the immune landscape in peripheral circulation in patients with high-altitude pulmonary hypertension (HAPH). We apply single-cell transcriptomics to characterize the monocytes that are significantly enriched in the peripheral blood mononuclear cells (PBMC) of HAPH patients. We discover an increase in C1 (non-classical) and C2 (intermediate) monocytes in PBMCs and a decrease in hypoxia-inducible transcription factor-1α (HIF-1α) in all monocyte subsets associated with HAPH. In addition, we demonstrate that similar immune adaptations may exist in HAPH and PH. Overall, we characterize an immune cell atlas of the peripheral blood in HAPH patients. Our data provide evidence that specific monocyte subsets and HIF-1α downregulation might be implicated in the pathogenesis of HAPH.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-37527-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37527-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-37527-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().