Effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17

Francisco Tsz Tsun Lai, Min Fan, Caige Huang, Celine Sze Ling Chui, Eric Yuk Fai Wan, Xue Li, Carlos King Ho Wong, Ching-Lung Cheung, Ian Chi Kei Wong () and Esther Wai Yin Chan ()
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Francisco Tsz Tsun Lai: The University of Hong Kong
Min Fan: The University of Hong Kong
Caige Huang: The University of Hong Kong
Celine Sze Ling Chui: Hong Kong Science Park
Eric Yuk Fai Wan: The University of Hong Kong
Xue Li: The University of Hong Kong
Carlos King Ho Wong: The University of Hong Kong
Ching-Lung Cheung: The University of Hong Kong
Ian Chi Kei Wong: The University of Hong Kong
Esther Wai Yin Chan: The University of Hong Kong

Nature Communications, 2023, vol. 14, issue 1, 1-6

Abstract: Abstract Extended intervals between the first and second doses of mRNA Covid-19 vaccines may reduce the risk of myocarditis in children and adolescents. However, vaccine effectiveness after this extension remains unclear. To examine this potential variable effectiveness, we conducted a population-based nested case-control study of children and adolescents aged 5–17 years who had received two doses of BNT162b2 in Hong Kong. From January 1 to August 15, 2022, 5396 Covid-19 cases and 202 Covid-19 related hospitalizations were identified and matched with 21,577 and 808 controls, respectively. For vaccine recipients with extended intervals [≥28 days, adjusted odds ratio 0.718, 95% Confidence Interval: 0.619, 0.833] there was a 29.2%-reduced risk of Covid-19 infection compared to those with regular intervals (21–27 days). If the threshold was set at eight weeks, the risk reduction was estimated at 43.5% (aOR 0.565, 95% CI: 0.456, 0.700). In conclusion, longer dosing intervals for children and adolescents should be considered.

Date: 2023
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DOI: 10.1038/s41467-023-37556-z

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