In situ orderly self-assembly strategy affording NIR-II-J-aggregates for in vivo imaging and surgical navigation

Zhe Li, Ping-Zhao Liang, Li Xu, Xing-Xing Zhang, Ke Li, Qian Wu, Xiao-Feng Lou, Tian-Bing Ren, Lin Yuan and Xiao-Bing Zhang ()
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Zhe Li: Hunan University
Ping-Zhao Liang: Hunan University
Li Xu: Hunan University
Xing-Xing Zhang: Hunan University
Ke Li: Hunan University
Qian Wu: Hunan University
Xiao-Feng Lou: Hunan University
Tian-Bing Ren: Hunan University
Lin Yuan: Hunan University
Xiao-Bing Zhang: Hunan University

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract J-aggregation, an effective strategy to extend wavelength, has been considered as a promising method for constructing NIR-II fluorophores. However, due to weak intermolecular interactions, conventional J-aggregates are easily decomposed into monomers in the biological environment. Although adding external carriers could help conventional J-aggregates stabilize, such methods still suffer from high-concentration dependence and are unsuitable for activatable probes design. Besides, these carriers-assisted nanoparticles are risky of disassembly in lipophilic environment. Herein, by fusing the precipitated dye (HPQ) which has orderly self-assembly structure, onto simple hemi-cyanine conjugated system, we construct a series of activatable, high-stability NIR-II-J-aggregates which overcome conventional J-aggregates carrier’s dependence and could in situ self-assembly in vivo. Further, we employ the NIR-II-J-aggregates probe HPQ-Zzh-B to achieve the long-term in situ imaging of tumor and precise tumor resection by NIR-II imaging navigation for reducing lung metastasis. We believe this strategy will advance the development of controllable NIR-II-J-aggregates and precise bioimaging in vivo.

Date: 2023
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DOI: 10.1038/s41467-023-37586-7

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