Single-shot isotropic differential interference contrast microscopy

Xinwei Wang, Hao Wang, Jinlu Wang, Xingsi Liu, Huijie Hao, You Sin Tan, Yilei Zhang, He Zhang, Xiangyan Ding, Weisong Zhao, Yuhang Wang, Zhengang Lu, Jian Liu, Joel K. W. Yang, Jiubin Tan, Haoyu Li (), Cheng-Wei Qiu (), Guangwei Hu () and Xumin Ding ()
Additional contact information
Xinwei Wang: Harbin Institute of Technology
Hao Wang: Singapore University of Technology and Design
Jinlu Wang: Harbin Medical University Cancer Hospital, Harbin Medical University
Xingsi Liu: National University of Singapore
Huijie Hao: Harbin Institute of Technology
You Sin Tan: Singapore University of Technology and Design
Yilei Zhang: Harbin Institute of Technology
He Zhang: Harbin Institute of Technology
Xiangyan Ding: Harbin Institute of Technology
Weisong Zhao: Harbin Institute of Technology
Yuhang Wang: Northeast Forestry University
Zhengang Lu: Harbin Institute of Technology
Jian Liu: Harbin Institute of Technology
Joel K. W. Yang: Singapore University of Technology and Design
Jiubin Tan: Harbin Institute of Technology
Haoyu Li: Harbin Institute of Technology
Cheng-Wei Qiu: National University of Singapore
Guangwei Hu: 50 Nanyang Avenue, Nanyang Technological University
Xumin Ding: Harbin Institute of Technology

Nature Communications, 2023, vol. 14, issue 1, 1-9

Abstract: Abstract Differential interference contrast (DIC) microscopy allows high-contrast, low-phototoxicity, and label-free imaging of transparent biological objects, and has been applied in the field of cellular morphology, cell segmentation, particle tracking, optical measurement and others. Commercial DIC microscopy based on Nomarski or Wollaston prism resorts to the interference of two polarized waves with a lateral differential offset (shear) and axial phase shift (bias). However, the shear generated by these prisms is limited to the rectilinear direction, unfortunately resulting in anisotropic contrast imaging. Here we propose an ultracompact metasurface-assisted isotropic DIC (i-DIC) microscopy based on a grand original pattern of radial shear interferometry, that converts the rectilinear shear into rotationally symmetric along radial direction, enabling single-shot isotropic imaging capabilities. The i-DIC presents a complementary fusion of typical meta-optics, traditional microscopes and integrated optical system, and showcases the promising and synergetic advancements in edge detection, particle motion tracking, and label-free cellular imaging.

Date: 2023
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DOI: 10.1038/s41467-023-37606-6

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