Amyloid-polysaccharide interfacial coacervates as therapeutic materials

Mohammad Peydayesh, Sabrina Kistler, Jiangtao Zhou, Viviane Lutz-Bueno, Francesca Damiani Victorelli, Andréia Bagliotti Meneguin, Larissa Spósito, Tais Maria Bauab, Marlus Chorilli and Raffaele Mezzenga ()
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Mohammad Peydayesh: ETH Zurich, Department of Health Sciences and Technology
Sabrina Kistler: ETH Zurich, Department of Materials
Jiangtao Zhou: ETH Zurich, Department of Health Sciences and Technology
Viviane Lutz-Bueno: ETH Zurich, Department of Health Sciences and Technology
Francesca Damiani Victorelli: ETH Zurich, Department of Health Sciences and Technology
Andréia Bagliotti Meneguin: School of Pharmaceutical Sciences, São Paulo State University
Larissa Spósito: School of Pharmaceutical Sciences, São Paulo State University
Tais Maria Bauab: São Paulo State University
Marlus Chorilli: School of Pharmaceutical Sciences, São Paulo State University
Raffaele Mezzenga: ETH Zurich, Department of Health Sciences and Technology

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Coacervation via liquid-liquid phase separation provides an excellent opportunity to address the challenges of designing nanostructured biomaterials with multiple functionalities. Protein-polysaccharide coacervates, in particular, offer an appealing strategy to target biomaterial scaffolds, but these systems suffer from the low mechanical and chemical stabilities of protein-based condensates. Here we overcome these limitations by transforming native proteins into amyloid fibrils and demonstrate that the coacervation of cationic protein amyloids and anionic linear polysaccharides results in the interfacial self-assembly of biomaterials with precise control of their structure and properties. The coacervates present a highly ordered asymmetric architecture with amyloid fibrils on one side and the polysaccharide on the other. We demonstrate the excellent performance of these coacervates for gastric ulcer protection by validating via an in vivo assay their therapeutic effect as engineered microparticles. These results point at amyloid-polysaccharides coacervates as an original and effective biomaterial for multiple uses in internal medicine.

Date: 2023
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DOI: 10.1038/s41467-023-37629-z

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