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The problem of selection bias in studies of pre-mRNA splicing

Zachary W. Dwyer and Jeffrey A. Pleiss ()
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Zachary W. Dwyer: Cornell University
Jeffrey A. Pleiss: Cornell University

Nature Communications, 2023, vol. 14, issue 1, 1-5

Abstract: Here we demonstrate how selection bias in studies of pre-mRNA splicing can inadvertently lead to inaccurate biological conclusions which nevertheless appear statistically robust. We argue that this may be a pervasive problem with potentially significant consequences for the field.

Date: 2023
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DOI: 10.1038/s41467-023-37650-2

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