Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis

Erin A. Catton, Daniel A. Bonsor, Carolina Herrera, Margaretha Stålhammar-Carlemalm, Mykola Lyndin, Claire E. Turner, Jo Soden, Jos A. G. Strijp, Bernhard B. Singer, Nina M. Sorge (), Gunnar Lindahl () and Alex J. McCarthy ()
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Erin A. Catton: Imperial College London
Daniel A. Bonsor: University of Maryland
Carolina Herrera: Imperial College London
Margaretha Stålhammar-Carlemalm: Lund University
Mykola Lyndin: Sumy State University
Claire E. Turner: The University of Sheffield
Jo Soden: Retrogenix, Chinley, High Peak
Jos A. G. Strijp: UMC Utrecht
Bernhard B. Singer: University of Duisburg-Essen
Nina M. Sorge: UMC Utrecht
Gunnar Lindahl: Lund University
Alex J. McCarthy: Imperial College London

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Life-threatening bacterial infections in women after childbirth, known as puerperal sepsis, resulted in classical epidemics and remain a global health problem. While outbreaks of puerperal sepsis have been ascribed to Streptococcus pyogenes, little is known about disease mechanisms. Here, we show that the bacterial R28 protein, which is epidemiologically associated with outbreaks of puerperal sepsis, specifically targets the human receptor CEACAM1. This interaction triggers events that would favor the development of puerperal sepsis, including adhesion to cervical cells, suppression of epithelial wound repair and subversion of innate immune responses. High-resolution structural analysis showed that an R28 domain with IgI3-like fold binds to the N-terminal domain of CEACAM1. Together, these findings demonstrate that a single adhesin-receptor interaction can drive the pathogenesis of bacterial sepsis and provide molecular insights into the pathogenesis of one of the most important infectious diseases in medical history.

Date: 2023
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DOI: 10.1038/s41467-023-37732-1

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