Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice

Han Guo, Jian-Bo Jiang, Wei Xu, Mu-Tian Zhang, Hui Chen, Huan-Ying Shi, Lu Wang, Miao He, Michael Lazarus, Shan-Qun Li (), Zhi-Li Huang () and Wei-Min Qu ()
Additional contact information
Han Guo: Fudan University
Jian-Bo Jiang: Fudan University
Wei Xu: Fudan University
Mu-Tian Zhang: Fudan University
Hui Chen: Fudan University
Huan-Ying Shi: Fudan University
Lu Wang: Fudan University
Miao He: Fudan University
Michael Lazarus: University of Tsukuba
Shan-Qun Li: Fudan University
Zhi-Li Huang: Fudan University
Wei-Min Qu: Fudan University

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract The parasubthalamic nucleus (PSTN) is considered to be involved in motivation, feeding and hunting, all of which are highly depending on wakefulness. However, the roles and underlying neural circuits of the PSTN in wakefulness remain unclear. Neurons expressing calretinin (CR) account for the majority of PSTN neurons. In this study in male mice, fiber photometry recordings showed that the activity of PSTNCR neurons increased at the transitions from non-rapid eye movement (non-REM, NREM) sleep to either wakefulness or REM sleep, as well as exploratory behavior. Chemogenetic and optogenetic experiments demonstrated that PSTNCR neurons were necessary for initiating and/or maintaining arousal associated with exploration. Photoactivation of projections of PSTNCR neurons revealed that they regulated exploration-related wakefulness by innervating the ventral tegmental area. Collectively, our findings indicate that PSTNCR circuitry is essential for the induction and maintenance of the awake state associated with exploration.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-37797-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37797-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-37797-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().