Exploiting synergistic effect of CO/NO gases for soft tissue transplantation using a hydrogel patch

Xiaoduo Tang, Jingyan Ren, Xin Wei, Tao Wang, Haiqiu Li, Yihan Sun, Yang Liu, Mingli Chi, Shoujun Zhu (), Laijin Lu (), Junhu Zhang () and Bai Yang
Additional contact information
Xiaoduo Tang: The First Hospital of Jilin University, Jilin University
Jingyan Ren: The First Hospital of Jilin University, Jilin University
Xin Wei: The First Hospital of Jilin University, Jilin University
Tao Wang: The First Hospital of Jilin University, Jilin University
Haiqiu Li: The First Hospital of Jilin University, Jilin University
Yihan Sun: The First Hospital of Jilin University, Jilin University
Yang Liu: The First Hospital of Jilin University, Jilin University
Mingli Chi: The First Hospital of Jilin University, Jilin University
Shoujun Zhu: The First Hospital of Jilin University, Jilin University
Laijin Lu: The First Hospital of Jilin University, Jilin University
Junhu Zhang: The First Hospital of Jilin University, Jilin University
Bai Yang: The First Hospital of Jilin University, Jilin University

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Autologous skin flap transplantation is a common method for repairing complex soft tissue defects caused by cancer, trauma, and congenital malformations. Limited blood supply range and post-transplantation ischemia-reperfusion injury can lead to distal necrosis of the flap and long-term functional loss, which severely restricts the decision-making regarding the optimal surgical plan. To address this issue, we develop a hydrogel patch that releases carbon monoxide and nitric oxide gases on demand, to afford a timely blood supply for skin flap transplantation during surgery. Using an ischemia-reperfusion dorsal skin flap model in rats, we show that the hydrogel patch maintains the immediate opening of blood flow channels in transplanted tissue and effective blood perfusion throughout the perioperative period, activating perfusion of the hemodynamic donor site. We demonstrate that the hydrogel patch promotes distal vascularization and long-term functional reconstruction of transplanted tissues by inhibiting inflammatory damage and accelerating blood vessel formation.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-023-37959-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37959-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-37959-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().