Altered human gut virome in patients undergoing antibiotics therapy for Helicobacter pylori

Lingling Wang, Haobin Yao, Daniel C. Morgan, Kam Shing Lau, Suet Yi Leung, Joshua W. K. Ho and Wai K. Leung ()
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Lingling Wang: The University of Hong Kong
Haobin Yao: The University of Hong Kong
Daniel C. Morgan: The University of Hong Kong
Kam Shing Lau: The University of Hong Kong
Suet Yi Leung: The University of Hong Kong, Pokfulam
Joshua W. K. Ho: The University of Hong Kong
Wai K. Leung: The University of Hong Kong

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Transient gut microbiota alterations have been reported after antibiotic therapy for Helicobacter pylori. However, alteration in the gut virome after H. pylori eradication remains uncertain. Here, we apply metagenomic sequencing to fecal samples of 44 H. pylori-infected patients at baseline, 6-week (N = 44), and 6-month (N = 33) after treatment. Following H. pylori eradication, we discover contraction of the gut virome diversity, separation of virome community with increased community difference, and shifting towards a higher proportion of core virus. While the gut microbiota is altered at 6-week and restored at 6-month, the virome community shows contraction till 6-month after the treatment with enhanced phage-bacteria interactions at 6-week. Multiple courses of antibiotic treatments further lead to lower virus community diversity when compared with treatment naive patients. Our results demonstrate that H. pylori eradication therapies not only result in transient alteration in gut microbiota but also significantly alter the previously less known gut virome community.

Date: 2023
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DOI: 10.1038/s41467-023-37975-y

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