Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study

Louise Grahnemo (), Maria Nethander, Eivind Coward, Maiken Elvestad Gabrielsen, Satya Sree, Jean-Marc Billod, Klara Sjögren, Lars Engstrand, Koen F. Dekkers, Tove Fall, Arnulf Langhammer, Kristian Hveem and Claes Ohlsson
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Louise Grahnemo: University of Gothenburg
Maria Nethander: University of Gothenburg
Eivind Coward: NTNU, Norwegian University of Science and Technology
Maiken Elvestad Gabrielsen: NTNU, Norwegian University of Science and Technology
Satya Sree: Bio-Me, Oslo Science Park
Jean-Marc Billod: Bio-Me, Oslo Science Park
Klara Sjögren: University of Gothenburg
Lars Engstrand: Tumor and Cell Biology, Centre for Translational Microbiome Research, Karolinska Institutet, Karolinska Hospital, Biomedicum A8
Koen F. Dekkers: Uppsala University
Tove Fall: Uppsala University
Arnulf Langhammer: NTNU, Norwegian University of Science and Technology
Kristian Hveem: NTNU, Norwegian University of Science and Technology
Claes Ohlsson: University of Gothenburg

Nature Communications, 2023, vol. 14, issue 1, 1-9

Abstract: Abstract Appendicular lean mass (ALM) associates with mobility and bone mineral density (BMD). While associations between gut microbiota composition and ALM have been reported, previous studies rely on relatively small sample sizes. Here, we determine the associations between prevalent gut microbes and ALM in large discovery and replication cohorts with information on relevant confounders within the population-based Norwegian HUNT cohort (n = 5196, including women and men). We show that the presence of three bacterial species – Coprococcus comes, Dorea longicatena, and Eubacterium ventriosum – are reproducibly associated with higher ALM. When combined into an anabolic species count, participants with all three anabolic species have 0.80 kg higher ALM than those without any. In an exploratory analysis, the anabolic species count is positively associated with femoral neck and total hip BMD. We conclude that the anabolic species count may be used as a marker of ALM and BMD. The therapeutic potential of these anabolic species to prevent sarcopenia and osteoporosis needs to be determined.

Date: 2023
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DOI: 10.1038/s41467-023-37978-9

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