HAPLN1 potentiates peritoneal metastasis in pancreatic cancer

Lena Wiedmann, Francesca De Angelis Rigotti, Nuria Vaquero-Siguero, Elisa Donato, Elisa Espinet, Iris Moll, Elisenda Alsina-Sanchis, Hanibal Bohnenberger, Elena Fernandez-Florido, Ronja Mülfarth, Margherita Vacca, Jennifer Gerwing, Lena-Christin Conradi, Philipp Ströbel, Andreas Trumpp, Carolin Mogler, Andreas Fischer () and Juan Rodriguez-Vita ()
Additional contact information
Lena Wiedmann: German Cancer Research Center (DKFZ)
Francesca De Angelis Rigotti: German Cancer Research Center (DKFZ)
Nuria Vaquero-Siguero: German Cancer Research Center (DKFZ)
Elisa Donato: German Cancer Research Center (DKFZ)
Elisa Espinet: German Cancer Research Center (DKFZ)
Iris Moll: German Cancer Research Center (DKFZ)
Elisenda Alsina-Sanchis: German Cancer Research Center (DKFZ)
Hanibal Bohnenberger: University Medical Center Göttingen, Georg-August-University
Elena Fernandez-Florido: German Cancer Research Center (DKFZ)
Ronja Mülfarth: German Cancer Research Center (DKFZ)
Margherita Vacca: German Cancer Research Center (DKFZ)
Jennifer Gerwing: German Cancer Research Center (DKFZ)
Lena-Christin Conradi: University Medical Center Göttingen
Philipp Ströbel: University Medical Center Göttingen, Georg-August-University
Andreas Trumpp: German Cancer Research Center (DKFZ)
Carolin Mogler: Technical University of Munich
Andreas Fischer: German Cancer Research Center (DKFZ)
Juan Rodriguez-Vita: German Cancer Research Center (DKFZ)

Nature Communications, 2023, vol. 14, issue 1, 1-18

Abstract: Abstract Pancreatic ductal adenocarcinoma (PDAC) frequently metastasizes into the peritoneum, which contributes to poor prognosis. Metastatic spreading is promoted by cancer cell plasticity, yet its regulation by the microenvironment is incompletely understood. Here, we show that the presence of hyaluronan and proteoglycan link protein-1 (HAPLN1) in the extracellular matrix enhances tumor cell plasticity and PDAC metastasis. Bioinformatic analysis showed that HAPLN1 expression is enriched in the basal PDAC subtype and associated with worse overall patient survival. In a mouse model for peritoneal carcinomatosis, HAPLN1-induced immunomodulation favors a more permissive microenvironment, which accelerates the peritoneal spread of tumor cells. Mechanistically, HAPLN1, via upregulation of tumor necrosis factor receptor 2 (TNFR2), promotes TNF-mediated upregulation of Hyaluronan (HA) production, facilitating EMT, stemness, invasion and immunomodulation. Extracellular HAPLN1 modifies cancer cells and fibroblasts, rendering them more immunomodulatory. As such, we identify HAPLN1 as a prognostic marker and as a driver for peritoneal metastasis in PDAC.

Date: 2023
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DOI: 10.1038/s41467-023-38064-w

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