An interactive murine single-cell atlas of the lung responses to radiation injury

Sandra Curras-Alonso, Juliette Soulier, Thomas Defard, Christian Weber, Sophie Heinrich, Hugo Laporte, Sophie Leboucher, Sonia Lameiras, Marie Dutreix, Vincent Favaudon, Florian Massip, Thomas Walter, Florian Mueller, José-Arturo Londoño-Vallejo () and Charles Fouillade ()
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Sandra Curras-Alonso: Sorbonne Universite, PSL University
Juliette Soulier: Sorbonne Universite, PSL University
Thomas Defard: PSL University
Christian Weber: Université Paris Cité
Sophie Heinrich: University Paris-Saclay, PSL University, Centre Universitaire
Hugo Laporte: Sorbonne Universite, PSL University
Sophie Leboucher: University Paris-Saclay, PSL University, Centre Universitaire
Sonia Lameiras: Institut Curie Genomics of Excellence (ICGex) Platform
Marie Dutreix: University Paris-Saclay, PSL University, Centre Universitaire
Vincent Favaudon: University Paris-Saclay, PSL University, Centre Universitaire
Florian Massip: PSL University
Thomas Walter: PSL University
Florian Mueller: Université Paris Cité
José-Arturo Londoño-Vallejo: Sorbonne Universite, PSL University
Charles Fouillade: University Paris-Saclay, PSL University, Centre Universitaire

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Radiation Induced Lung Injury (RILI) is one of the main limiting factors of thorax irradiation, which can induce acute pneumonitis as well as pulmonary fibrosis, the latter being a life-threatening condition. The order of cellular and molecular events in the progression towards fibrosis is key to the physiopathogenesis of the disease, yet their coordination in space and time remains largely unexplored. Here, we present an interactive murine single cell atlas of the lung response to irradiation, generated from C57BL6/J female mice. This tool opens the door for exploration of the spatio-temporal dynamics of the mechanisms that lead to radiation-induced pulmonary fibrosis. It depicts with unprecedented detail cell type-specific radiation-induced responses associated with either lung regeneration or the failure thereof. A better understanding of the mechanisms leading to lung fibrosis will help finding new therapeutic options that could improve patients’ quality of life.

Date: 2023
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DOI: 10.1038/s41467-023-38134-z

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