Structural basis for the self-recognition of sDSCAM in Chelicerata

Jie Cheng, Yamei Yu, Xingyu Wang, Xi Zheng, Ting Liu, Daojun Hu, Yongfeng Jin, Ying Lai, Tian-Min Fu and Qiang Chen ()
Additional contact information
Jie Cheng: Sichuan University
Yamei Yu: West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Xingyu Wang: West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Xi Zheng: Sichuan University
Ting Liu: West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Daojun Hu: West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Yongfeng Jin: Zhejiang University
Ying Lai: Sichuan University
Tian-Min Fu: The Ohio State University
Qiang Chen: West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy

Nature Communications, 2023, vol. 14, issue 1, 1-12

Abstract: Abstract To create a functional neural circuit, neurons develop a molecular identity to discriminate self from non-self. The invertebrate Dscam family and vertebrate Pcdh family are implicated in determining synaptic specificity. Recently identified in Chelicerata, a shortened Dscam (sDscam) has been shown to resemble the isoform-generating characters of both Dscam and Pcdh and represent an evolutionary transition. Here we presented the molecular details of sDscam self-recognition via both trans and cis interactions using X-ray crystallographic data and functional assays. Based on our results, we proposed a molecular zipper model for the assemblies of sDscam to mediate cell-cell recognition. In this model, sDscam utilized FNIII domain to form side-by-side interactions with neighboring molecules in the same cell while established hand-in-hand interactions via Ig1 domain with molecules from another cell around. Together, our study provided a framework for understanding the assembly, recognition, and evolution of sDscam.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-38205-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38205-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-38205-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().