Photocatalyzed regioselective hydrosilylation for the divergent synthesis of geminal and vicinal borosilanes

Degong Kong, Muliang Zhang, Yuchao Zhang, Zhenyang Yu, Hui Cao () and Jie Wu ()
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Degong Kong: National University of Singapore
Muliang Zhang: National University of Singapore
Yuchao Zhang: Institute of Basic Medicine and Cancer (IBMC), Cancer Hospital of the University of Chinese Academy of Sciences
Zhenyang Yu: National University of Singapore
Hui Cao: National University of Singapore
Jie Wu: National University of Singapore

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract Geminal and vicinal borosilanes are useful building blocks in synthetic chemistry and material science. Hydrosilylation/hydroborylation of unsaturated systems offer expedient access to these motifs. In contrast to the well-established transition-metal-catalyzed methods, radical approaches are rarely explored. Herein we report the synthesis of geminal borosilanes from α-selective hydrosilylation of alkenyl boronates via photoinduced hydrogen atom transfer (HAT) catalysis. Mechanistic studies implicate that the α-selectivity originates from a kinetically favored radical addition and an energetically favored HAT process. We further demonstrate selective synthesis of vicinal borosilanes through hydrosilylation of allyl boronates via 1,2-boron radical migration. These strategies exhibit broad scopes across primary, secondary, and tertiary silanes and various boron compounds. The synthetic utility is evidenced by access to multi-borosilanes in a diverse fashion and scaling up by continuous-flow synthesis.

Date: 2023
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DOI: 10.1038/s41467-023-38224-y

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