The impact of introduction of the 10-valent pneumococcal conjugate vaccine on pneumococcal carriage in Nigeria

Aishatu L. Adamu (), J. Ojal, Isa A. Abubakar, Kofo A. Odeyemi, Musa M. Bello, Christy A. N. Okoromah, Boniface Karia, Angela Karani, Donald. Akech, Victor Inem, J. Anthony G. Scott and Ifedayo M. O. Adetifa
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Aishatu L. Adamu: KEMRI-Wellcome Trust Research Programme
J. Ojal: KEMRI-Wellcome Trust Research Programme
Isa A. Abubakar: College of Health Sciences, Bayero University, Kano/Aminu Kano Teaching Hospital
Kofo A. Odeyemi: College of Medicine, University of Lagos
Musa M. Bello: College of Health Sciences, Bayero University, Kano/Aminu Kano Teaching Hospital
Christy A. N. Okoromah: College of Medicine, University of Lagos
Boniface Karia: KEMRI-Wellcome Trust Research Programme
Angela Karani: KEMRI-Wellcome Trust Research Programme
Donald. Akech: KEMRI-Wellcome Trust Research Programme
Victor Inem: College of Medicine, University of Lagos
J. Anthony G. Scott: KEMRI-Wellcome Trust Research Programme
Ifedayo M. O. Adetifa: KEMRI-Wellcome Trust Research Programme

Nature Communications, 2023, vol. 14, issue 1, 1-9

Abstract: Abstract Pneumococcal conjugate vaccines (PCVs) protect against invasive pneumococcal disease (IPD) among vaccinees. However, at population level, this protection is driven by indirect effects. PCVs prevent nasopharyngeal acquisition of vaccine-serotype (VT) pneumococci, reducing onward transmission. Each disease episode is preceded by infection from a carrier, so vaccine impacts on carriage provide a minimum estimate of disease reduction in settings lacking expensive IPD surveillance. We documented carriage prevalence and vaccine coverage in two settings in Nigeria annually (2016–2020) following PCV10 introduction in 2016. Among 4,684 rural participants, VT carriage prevalence fell from 21 to 12% as childhood (

Date: 2023
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DOI: 10.1038/s41467-023-38277-z

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