Roles of adenine methylation in the physiology of Lacticaseibacillus paracasei

Jie Zhao, Meng Zhang, Wenyan Hui, Yue Zhang, Jing Wang, Shaojing Wang, Lai-Yu Kwok, Jian Kong, Heping Zhang and Wenyi Zhang ()
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Jie Zhao: Inner Mongolia Agricultural University
Meng Zhang: Inner Mongolia Agricultural University
Wenyan Hui: Inner Mongolia Agricultural University
Yue Zhang: Inner Mongolia Agricultural University
Jing Wang: Inner Mongolia Agricultural University
Shaojing Wang: College of Life Sciences, Nankai University
Lai-Yu Kwok: Inner Mongolia Agricultural University
Jian Kong: Shandong University
Heping Zhang: Inner Mongolia Agricultural University
Wenyi Zhang: Inner Mongolia Agricultural University

Nature Communications, 2023, vol. 14, issue 1, 1-12

Abstract: Abstract Lacticaseibacillus paracasei is an economically important bacterial species, used in the food industry and as a probiotic. Here, we investigate the roles of N6-methyladenine (6mA) modification in L. paracasei using multi-omics and high-throughput chromosome conformation capture (Hi-C) analyses. The distribution of 6mA-modified sites varies across the genomes of 28 strains, and appears to be enriched near genes involved in carbohydrate metabolism. A pglX mutant, defective in 6mA modification, shows transcriptomic alterations but only modest changes in growth and genomic spatial organization.

Date: 2023
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DOI: 10.1038/s41467-023-38291-1

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