AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration

Eva Crosas-Molist, Vittoria Graziani, Oscar Maiques, Pahini Pandya, Joanne Monger, Remi Samain, Samantha L. George, Saba Malik, Jerrine Salise, Valle Morales, Adrien Le Guennec, R. Andrew Atkinson, Rosa M. Marti, Xavier Matias-Guiu, Guillaume Charras, Maria R. Conte, Alberto Elosegui-Artola, Mark Holt and Victoria Sanz-Moreno ()
Additional contact information
Eva Crosas-Molist: Charterhouse Square
Vittoria Graziani: Charterhouse Square
Oscar Maiques: Charterhouse Square
Pahini Pandya: Guy’s Campus, King’s College London
Joanne Monger: Charterhouse Square
Remi Samain: Charterhouse Square
Samantha L. George: Charterhouse Square
Saba Malik: Guy’s Campus, King’s College London
Jerrine Salise: Guy’s Campus, King’s College London
Valle Morales: Charterhouse Square
Adrien Le Guennec: Guy’s Campus, King’s College London
R. Andrew Atkinson: Guy’s Campus, King’s College London
Rosa M. Marti: University of Lleida, CIBERONC, IRB Lleida
Xavier Matias-Guiu: University of Lleida, IRB Lleida, CIBERONC
Guillaume Charras: University College London
Maria R. Conte: Guy’s Campus, King’s College London
Alberto Elosegui-Artola: The Francis Crick Institute
Mark Holt: Guy’s Campus, King’s College London
Victoria Sanz-Moreno: Charterhouse Square

Nature Communications, 2023, vol. 14, issue 1, 1-22

Abstract: Abstract Cell migration is crucial for cancer dissemination. We find that AMP-activated protein kinase (AMPK) controls cell migration by acting as an adhesion sensing molecular hub. In 3-dimensional matrices, fast-migrating amoeboid cancer cells exert low adhesion/low traction linked to low ATP/AMP, leading to AMPK activation. In turn, AMPK plays a dual role controlling mitochondrial dynamics and cytoskeletal remodelling. High AMPK activity in low adhering migratory cells, induces mitochondrial fission, resulting in lower oxidative phosphorylation and lower mitochondrial ATP. Concurrently, AMPK inactivates Myosin Phosphatase, increasing Myosin II-dependent amoeboid migration. Reducing adhesion or mitochondrial fusion or activating AMPK induces efficient rounded-amoeboid migration. AMPK inhibition suppresses metastatic potential of amoeboid cancer cells in vivo, while a mitochondrial/AMPK-driven switch is observed in regions of human tumours where amoeboid cells are disseminating. We unveil how mitochondrial dynamics control cell migration and suggest that AMPK is a mechano-metabolic sensor linking energetics and the cytoskeleton.

Date: 2023
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DOI: 10.1038/s41467-023-38292-0

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