Task-specific modulation of corticospinal neuron activity during motor learning in mice

Najet Serradj, Francesca Marino, Yunuen Moreno-López, Amanda Bernstein, Sydney Agger, Marwa Soliman, Andrew Sloan and Edmund Hollis ()
Additional contact information
Najet Serradj: Burke Neurological Institute
Francesca Marino: University of California
Yunuen Moreno-López: Burke Neurological Institute
Amanda Bernstein: Burke Neurological Institute
Sydney Agger: HAVAS Production Studios
Marwa Soliman: Burke Neurological Institute
Andrew Sloan: Vulintus, Inc.
Edmund Hollis: Burke Neurological Institute

Nature Communications, 2023, vol. 14, issue 1, 1-12

Abstract: Abstract Motor skill learning relies on the plasticity of the primary motor cortex as task acquisition drives cortical motor network remodeling. Large-scale cortical remodeling of evoked motor outputs occurs during the learning of corticospinal-dependent prehension behavior, but not simple, non-dexterous tasks. Here we determine the response of corticospinal neurons to two distinct motor training paradigms and assess the role of corticospinal neurons in the execution of a task requiring precise modulation of forelimb movement and one that does not. In vivo calcium imaging in mice revealed temporal coding of corticospinal activity coincident with the development of precise prehension movements, but not more simplistic movement patterns. Transection of the corticospinal tract and optogenetic regulation of corticospinal activity show the necessity for patterned corticospinal network activity in the execution of precise movements but not simplistic ones. Our findings reveal a critical role for corticospinal network modulation in the learning and execution of precise motor movements.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-38418-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38418-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-38418-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().