Single-cell analysis of gastric signet ring cell carcinoma reveals cytological and immune microenvironment features

Weizhu Zhao, Yanfei Jia, Guangyu Sun, Haiying Yang, Luguang Liu, Xianlin Qu, Jishuang Ding, Hang Yu, Botao Xu, Siwei Zhao, Ligang Xing () and Jie Chai ()
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Weizhu Zhao: Shandong University Cancer Center
Yanfei Jia: Shandong First Medical University
Guangyu Sun: Binzhou People’s Hospital Affiliated to Shandong First Medical University
Haiying Yang: Binzhou People’s Hospital Affiliated to Shandong First Medical University
Luguang Liu: Shandong First Medical University and Shandong Academy of Medical Sciences
Xianlin Qu: Shandong First Medical University and Shandong Academy of Medical Sciences
Jishuang Ding: Shandong First Medical University and Shandong Academy of Medical Sciences
Hang Yu: Shandong First Medical University and Shandong Academy of Medical Sciences
Botao Xu: Shandong First Medical University and Shandong Academy of Medical Sciences
Siwei Zhao: Shandong First Medical University and Shandong Academy of Medical Sciences
Ligang Xing: Shandong University Cancer Center
Jie Chai: Shandong First Medical University and Shandong Academy of Medical Sciences

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Gastric signet ring cell carcinoma (GSRC) is a special subtype of gastric cancer (GC) associated with poor prognosis, but an in-depth and systematic study of GSRC is lacking. Here, we perform single-cell RNA sequencing to assess GC samples. We identify signet ring cell carcinoma (SRCC) cells. Microseminoprotein-beta (MSMB) can be used as a marker gene to guide the identification of moderately/poorly differentiated adenocarcinoma and signet ring cell carcinoma (SRCC). The upregulated differentially expressed genes in SRCC cells are mainly enriched in abnormally activated cancer-related signalling pathways and immune response signalling pathways. SRCC cells are also significantly enriched in mitogen-activated protein kinase and oestrogen signalling pathways, which can interact and promote each other in a positive feedback loop. SRCC cells are shown to have lower cell adhesion and higher immune evasion capabilities as well as an immunosuppressive microenvironment, which may be closely associated with the relatively poor prognosis of GSRC. In summary, GSRC exhibits unique cytological characteristics and a unique immune microenvironment, which may be advantageous for accurate diagnosis and treatment.

Date: 2023
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DOI: 10.1038/s41467-023-38426-4

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