A local water molecular-heating strategy for near-infrared long-lifetime imaging-guided photothermal therapy of glioblastoma

Dongkyu Kang, Hyung Shik Kim, Soohyun Han, Yeonju Lee, Young-Pil Kim, Dong Yun Lee () and Joonseok Lee ()
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Dongkyu Kang: Hanyang University
Hyung Shik Kim: Hanyang University
Soohyun Han: Hanyang University
Yeonju Lee: Hanyang University
Young-Pil Kim: Hanyang University
Dong Yun Lee: Hanyang University
Joonseok Lee: Hanyang University

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Owing to the strong absorption of water in the near-infrared (NIR) region near 1.0 μm, this wavelength is considered unsuitable as an imaging and analytical signal in biological environments. However, 1.0 μm NIR can be converted into heat and used as a local water-molecular heating strategy for the photothermal therapy of biological tissues. Herein, we describe a Nd-Yb co-doped nanomaterial (water-heating nanoparticles (NPs)) as strong 1.0 μm emissive NPs to target the absorption band of water. Furthermore, introducing Tm ions into the water-heating NPs improve the NIR lifetime, enabling the development of a NIR imaging-guided water-heating probe (water-heating NIR NPs). In the glioblastoma multiforme male mouse model, tumor-targeted water-heating NIR NPs reduce the tumor volume by 78.9% in the presence of high-resolution intracranial NIR long-lifetime imaging. Hence, water-heating NIR NPs can be used as a promising nanomaterial for imaging and photothermal ablation in deep-tissue-bearing tumor therapy.

Date: 2023
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DOI: 10.1038/s41467-023-38451-3

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