Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

Oana A. Zeleznik (), Jae H. Kang, Jessica Lasky-Su, A. Heather Eliassen, Lisa Frueh, Clary B. Clish, Bernard A. Rosner, Tobias Elze, Pirro Hysi, Anthony Khawaja, Janey L. Wiggs and Louis R. Pasquale
Additional contact information
Oana A. Zeleznik: Brigham and Women’s Hospital
Jae H. Kang: Brigham and Women’s Hospital
Jessica Lasky-Su: Brigham and Women’s Hospital
A. Heather Eliassen: Brigham and Women’s Hospital
Lisa Frueh: Brigham and Women’s Hospital
Clary B. Clish: Broad Institute of Massachusetts Institute of Technology and Harvard
Bernard A. Rosner: Brigham and Women’s Hospital
Tobias Elze: Harvard Medical School
Pirro Hysi: King’s College London
Anthony Khawaja: Moorfields Eye Hospital
Janey L. Wiggs: Harvard Medical School
Louis R. Pasquale: Icahn School of Medicine at Mount Sinai

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Glaucoma is a progressive optic neuropathy and a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma is the most common form, and yet the etiology of this multifactorial disease is poorly understood. We aimed to identify plasma metabolites associated with the risk of developing POAG in a case-control study (599 cases and 599 matched controls) nested within the Nurses’ Health Studies, and Health Professionals’ Follow-Up Study. Plasma metabolites were measured with LC-MS/MS at the Broad Institute (Cambridge, MA, USA); 369 metabolites from 18 metabolite classes passed quality control analyses. For comparison, in a cross-sectional study in the UK Biobank, 168 metabolites were measured in plasma samples from 2,238 prevalent glaucoma cases and 44,723 controls using NMR spectroscopy (Nightingale, Finland; version 2020). Here we show higher levels of diglycerides and triglycerides are adversely associated with glaucoma in all four cohorts, suggesting that they play an important role in glaucoma pathogenesis.

Date: 2023
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DOI: 10.1038/s41467-023-38466-w

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