A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase

Vinitha N. Ragavan, Pramod C. Nair, Natalia Jarzebska, Ramcharan Singh Angom, Luana Ruta, Elisa Bianconi, Silvia Grottelli, Natalia D. Tararova, Daniel Ryazanskiy, Steven R. Lentz, Sara Tommasi, Jens Martens-Lobenhoffer, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Elena Rubets, Sarah Chau, Yingjie Chen, Xinli Hu, Nadine Bernhardt, Peter M. Spieth, Norbert Weiss, Stefan R. Bornstein, Debabrata Mukhopadhyay, Stefanie M. Bode-Böger, Renke Maas, Ying Wang, Antonio Macchiarulo, Arduino A. Mangoni, Barbara Cellini and Roman N. Rodionov ()
Additional contact information
Vinitha N. Ragavan: Technische Universität Dresden
Pramod C. Nair: Flinders University and Flinders Medical Centre, Bedford Park
Natalia Jarzebska: Technische Universität Dresden
Ramcharan Singh Angom: Mayo Clinic College of Medicine and Science
Luana Ruta: University of Perugia
Elisa Bianconi: University of Perugia
Silvia Grottelli: University of Perugia
Natalia D. Tararova: DAPCEL, Inc.
Daniel Ryazanskiy: DAPCEL, Inc.
Steven R. Lentz: The University of Iowa Carver College of Medicine
Sara Tommasi: Flinders University and Flinders Medical Centre, Bedford Park
Jens Martens-Lobenhoffer: Otto von Guericke University
Toshiko Suzuki-Yamamoto: Okayama Prefectural University
Masumi Kimoto: Okayama Prefectural University
Elena Rubets: Technische Universität Dresden
Sarah Chau: Mayo Clinic College of Medicine and Science
Yingjie Chen: University of Mississippi Medical Center
Xinli Hu: Beijing University
Nadine Bernhardt: University Hospital Carl Gustav Carus, Technische Universität Dresden
Peter M. Spieth: University Hospital Dresden, Technische Universität Dresden
Norbert Weiss: Technische Universität Dresden
Stefan R. Bornstein: Technische Universität Dresden
Debabrata Mukhopadhyay: Mayo Clinic College of Medicine and Science
Stefanie M. Bode-Böger: Otto von Guericke University
Renke Maas: Friedrich-Alexander-Universität Erlangen-Nürnberg
Ying Wang: Mayo Clinic College of Medicine and Science
Antonio Macchiarulo: University of Perugia
Arduino A. Mangoni: Flinders University and Flinders Medical Centre, Bedford Park
Barbara Cellini: University of Perugia
Roman N. Rodionov: Technische Universität Dresden

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Dimethylarginine dimethylaminohydrolase 1 (DDAH1) protects against cardiovascular disease by metabolising the risk factor asymmetric dimethylarginine (ADMA). However, the question whether the second DDAH isoform, DDAH2, directly metabolises ADMA has remained unanswered. Consequently, it is still unclear if DDAH2 may be a potential target for ADMA-lowering therapies or if drug development efforts should focus on DDAH2’s known physiological functions in mitochondrial fission, angiogenesis, vascular remodelling, insulin secretion, and immune responses. Here, an international consortium of research groups set out to address this question using in silico, in vitro, cell culture, and murine models. The findings uniformly demonstrate that DDAH2 is incapable of metabolising ADMA, thus resolving a 20-year controversy and providing a starting point for the investigation of alternative, ADMA-independent functions of DDAH2.

Date: 2023
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DOI: 10.1038/s41467-023-38467-9

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