The contributions of mitochondrial and nuclear mitochondrial genetic variation to neuroticism

Charley Xia, Sarah J. Pickett, David C. M. Liewald, Alexander Weiss, Gavin Hudson and W. David Hill ()
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Charley Xia: University of Edinburgh
Sarah J. Pickett: Newcastle University
David C. M. Liewald: University of Edinburgh
Alexander Weiss: University of Edinburgh
Gavin Hudson: Newcastle University
W. David Hill: University of Edinburgh

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Neuroticism is a heritable trait composed of separate facets, each conferring different levels of protection or risk, to health. By examining mitochondrial DNA in 269,506 individuals, we show mitochondrial haplogroups explain 0.07-0.01% of variance in neuroticism and identify five haplogroup and 15 mitochondria-marker associations across a general factor of neuroticism, and two special factors of anxiety/tension, and worry/vulnerability with effect sizes of the same magnitude as autosomal variants. Within-haplogroup genome-wide association studies identified H-haplogroup-specific autosomal effects explaining 1.4% variance of worry/vulnerability. These H-haplogroup-specific autosomal effects show a pleiotropic relationship with cognitive, physical and mental health that differs from that found when assessing autosomal effects across haplogroups. We identify interactions between chromosome 9 regions and mitochondrial haplogroups at P

Date: 2023
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DOI: 10.1038/s41467-023-38480-y

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