A biodegradable, flexible photonic patch for in vivo phototherapy

Kaicheng Deng, Yao Tang, Yan Xiao, Danni Zhong, Hua Zhang, Wen Fang, Liyin Shen, Zhaochuang Wang, Jiazhen Pan, Yuwen Lu, Changming Chen, Yun Gao, Qiao Jin, Lenan Zhuang, Hao Wan, Liujing Zhuang, Ping Wang, Junfeng Zhai, Tanchen Ren, Qiaoling Hu, Meidong Lang, Yue Zhang, Huanan Wang, Min Zhou (), Changyou Gao (), Lei Zhang () and Yang Zhu ()
Additional contact information
Kaicheng Deng: Zhejiang University
Yao Tang: Research Center for Humanoid Sensing, Zhejiang Lab
Yan Xiao: East China University of Science and Technology
Danni Zhong: Zhejiang University
Hua Zhang: Zhejiang University
Wen Fang: Zhejiang University
Liyin Shen: Zhejiang University
Zhaochuang Wang: East China University of Science and Technology
Jiazhen Pan: Zhejiang University
Yuwen Lu: Zhejiang University
Changming Chen: Zhejiang University
Yun Gao: Zhejiang University
Qiao Jin: Zhejiang University
Lenan Zhuang: Zhejiang University
Hao Wan: Zhejiang University
Liujing Zhuang: Zhejiang University
Ping Wang: Zhejiang University
Junfeng Zhai: Institute of Plant Quarantine, Chinese Academy of Inspection and Quarantine
Tanchen Ren: Zhejiang University
Qiaoling Hu: Zhejiang University
Meidong Lang: East China University of Science and Technology
Yue Zhang: San Francisco Veterans Affairs Medical Center
Huanan Wang: Zhejiang University
Min Zhou: Zhejiang University
Changyou Gao: Zhejiang University
Lei Zhang: Research Center for Humanoid Sensing, Zhejiang Lab
Yang Zhu: Zhejiang University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Diagnostic and therapeutic illumination on internal organs and tissues with high controllability and adaptability in terms of spectrum, area, depth, and intensity remains a major challenge. Here, we present a flexible, biodegradable photonic device called iCarP with a micrometer scale air gap between a refractive polyester patch and the embedded removable tapered optical fiber. ICarP combines the advantages of light diffraction by the tapered optical fiber, dual refractions in the air gap, and reflection inside the patch to obtain a bulb-like illumination, guiding light towards target tissue. We show that iCarP achieves large area, high intensity, wide spectrum, continuous or pulsatile, deeply penetrating illumination without puncturing the target tissues and demonstrate that it supports phototherapies with different photosensitizers. We find that the photonic device is compatible with thoracoscopy-based minimally invasive implantation onto beating hearts. These initial results show that iCarP could be a safe, precise and widely applicable device suitable for internal organs and tissue illumination and associated diagnosis and therapy.

Date: 2023
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DOI: 10.1038/s41467-023-38554-x

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