An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment

Guoqing Li, Su Liu, Yixiao Chen, Jin Zhao, Huihui Xu, Jian Weng, Fei Yu, Ao Xiong, Anjaneyulu Udduttula, Deli Wang, Peng Liu (), Yingqi Chen () and Hui Zeng ()
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Guoqing Li: Peking University Shenzhen Hospital
Su Liu: Peking University Shenzhen Hospital
Yixiao Chen: Peking University Shenzhen Hospital
Jin Zhao: Peking University Shenzhen Hospital
Huihui Xu: Peking University Shenzhen Hospital
Jian Weng: Peking University Shenzhen Hospital
Fei Yu: Peking University Shenzhen Hospital
Ao Xiong: Peking University Shenzhen Hospital
Anjaneyulu Udduttula: Vellore Institute of Technology (VIT)
Deli Wang: Peking University Shenzhen Hospital
Peng Liu: Peking University Shenzhen Hospital
Yingqi Chen: Peking University Shenzhen Hospital
Hui Zeng: Peking University Shenzhen Hospital

Nature Communications, 2023, vol. 14, issue 1, 1-18

Abstract: Abstract Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA), but it is hindered by rapid drug diffusion, thereby necessitating high-frequency injections. Hence, the development of a biofunctional hydrogel for improved delivery is required. In this study, we introduce a liposome-anchored teriparatide (PTH (1–34)) incorporated into a gallic acid-grafted gelatin injectable hydrogel (GLP hydrogel). We show that the GLP hydrogel can form in situ and without affecting knee motion after intra-articular injection in mice. We demonstrate controlled, sustained release of PTH (1–34) from the GLP hydrogel. We find that the GLP hydrogel promotes ATDC5 cell proliferation and protects the IL-1β-induced ATDC5 cells from further OA progression by regulating the PI3K/AKT signaling pathway. Further, we show that intra-articular injection of hydrogels into an OA-induced mouse model promotes glycosaminoglycans synthesis and protects the cartilage from degradation, supporting the potential of this biomaterial for OA treatment.

Date: 2023
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DOI: 10.1038/s41467-023-38597-0

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